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#1
Fri Feb 19, 2016, 08:08 AM
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methotrexate
anyone have info on methotrexate and its use in mds
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#2
Fri Feb 19, 2016, 08:22 AM
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Article on MDS
Attached is an article that mentions MDS and methotrexate.
Data
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Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
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#3
Fri Feb 19, 2016, 02:39 PM
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Leslie,
Methotrexate is frequently used in the conditioning regimen for stem cell transplant to suppress the immune system and try to prevent acute GVHD. It may have been used for other purposes in MDS as well, but it is not commonly used for treatment apart from stem cell transplant at least not so far as I know. The other place that I have seen it used is to treat ITP and RA. It would seem like if a person's MDS was immune mediated that it could be used for treatment as well.
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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