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#1
Tue Nov 14, 2017, 06:32 PM
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RUNX1 gene
Has anyone ever come across the RUNX1 gene? Testing for it, both in the blood and skin biopsy. My docs here in London seem interested in it and have done it to me recently and just curious if anyone has any insight?
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37/M. Feb 2008 Dx hypoplastic anemia. Watch and wait until Jan 2012, dx with hypoplastic MDS (RCMD). Sep 2012 ATG, on cyclo since. Partial remission, living very active life. 
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#2
Tue Nov 14, 2017, 07:09 PM
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lacanada1,
If you search for "RUNX1" on the search page you'll find a number of other threads that mention it.
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#3
Tue Nov 14, 2017, 08:28 PM
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Runx1
The following is from the web site:
http://www.genecards.org/cgi-bin/carddisp.pl?gene=RUNX1 RUNX1 is a transcription factor that forms a complex with the cofactor CBFB. This complex provides stability to the RUNX1 protein which is involved in the generation of hematopoietic stem cells and for their differentiation into myeloid and lymphoid lines. Loss of RUNX1 function has been shown to impair differentiation between myeloid and lymphoid lines often resulting in the development of leukemia. Data
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Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
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#4
Wed Nov 15, 2017, 05:16 AM
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Hey, I had runx1 prior to my stem cell transplant. It predisposes you to getting forms of cancer apparently. They have a new test in Australia which can pick up very small traces of it in your cells. My doctor wanted to make sure it was gone post transplant. Hope that helps 😊
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Now 30yr old. Diagnosed AML dec 2015 (Most likely MDS prior). Trisomy 6. Runx1 mutation also. Had induction and consolidation chemo. Marrow failure ++ so SCT on 21st of March with MUD. Married with a 1yr old!
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