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#276
Sat Aug 27, 2011, 03:05 PM
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We're Out of Here!
Hi All!
Well, it's been a good run, but I think it's time we closed down this Campath roadshow and moved on to greener pastures. Dr. Olnes' evaluation of my latest BMB is that response is unlikely at this late date; and, given my every other week transfusion schedule, it's time to try something new. A new therapy requires a new thread, no? So come look for me here, where I'm crowd sourcing my next therapy. I need your help researching my options. Take Care! Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at www.greghankins.com 
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#277
Sun Aug 28, 2011, 04:43 AM
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Hi Greg,
I can't add any insight, you are way ahead of me already. I'll also be interested in Dr. Olnes take. Blasts not worth mentioning, wow! And crowd sourcing? Did you invent that??
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Catherine, wife of Bruce age 75; diagnosed 6/10/11 with macrocytic anemia, neutropenia and mild thrombocytopenia; BMB suggesting emerging MDS. Copper deficient. Currently receiving procrit and neuopogen injections weekly, B12 dermal cream and injections, Transfusions ~ 5 weeks.
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#278
Sun Aug 28, 2011, 12:58 PM
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Hey Catherine!
I cannot take credit for crowd sourcing; I'm not sure who came up with that one. Dr. Olnes opined that my disappearing Trisomy 8 could be the result of the Campath, but, given my increased need for RBC transfusions, he doesn't expect further response. His first line recommendation is Revlimid, though I've asked him about ezatiostat, as well. So I'm in the hunt from promising new therapies for low-risk folks. Have a great Sunday! Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at www.greghankins.com
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#279
Tue Aug 30, 2011, 02:59 AM
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Hi Greg,
I have a question for you...How long after Campath is your CD4/CD8 ratio expected to be reversed? Could it be reversed because you still have some kind of auto immune attack going on in your system?
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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#280
Wed Aug 31, 2011, 10:44 PM
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Hi Hopeful!
Dr.Olnes tells me that the Campath-induced CD4/CD8 inversion lasts about two years. I gather that Campath knocks down lots of different T-cells and B-cells, but maybe knocks down the CD4s even more than the rest. Near as I can tell, it's an expected effect of the drug. Take care! Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at www.greghankins.com
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