Home         Forums  

Go Back   Marrowforums > Bone Marrow Failure Diseases > Bone Marrow Failure
Register FAQ Search Today's Posts Mark Forums Read

Bone Marrow Failure Causes, treatment approaches, terminology, related diseases

Reply
 
Thread Tools Search this Thread
  #1  
Old Wed Mar 9, 2011, 06:30 AM
edithr edithr is offline
Member
 
Join Date: Feb 2011
Location: 30 mi West of Cleveland
Posts: 86
telomere length

Anybody here ever had this test? Or hear of it?

http://www.nih.gov/researchmatters/s...2010anemia.htm

Thanks.
Reply With Quote
  #2  
Old Wed Mar 9, 2011, 11:45 AM
Birgitta-A Birgitta-A is offline
Member
 
Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Telomer length

Hi edithr,
As far as I understand this test is still only done in trials.
http://ash.confex.com/ash/2008/webpr...Paper7294.html
Kind regards
Birgitta-A
71 yo, dx MDS Interm-1 2006, Thalidomide 50 mg 4 caps/week, Prednisone 5 mg, Exjade 500 mg and Neupogen 2 injections/week.
Reply With Quote
  #3  
Old Thu Mar 10, 2011, 06:24 AM
edithr edithr is offline
Member
 
Join Date: Feb 2011
Location: 30 mi West of Cleveland
Posts: 86
They're testing my son, along with mine and my husbands blood for it. Through a research project. I know it's early in the morning, but I couldn't read the article, it was too technical for my puny brain. Maybe later today it'll make more sense.
Reply With Quote
  #4  
Old Thu Mar 10, 2011, 11:18 AM
Birgitta-A Birgitta-A is offline
Member
 
Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Telomere lengths

Hi edithr,
Read only the results :
1.Telomere lengths in whole blood were significantly shorter among MDS cases.

2. Among MDS cases, telomere lengths in whole blood differed by MDS subtype, ranging from a mean T/S ratio of 2.2 in patients with refractory anemia to 4.3 in patients with refractory anemia with ringed sideroblasts.

3. MDS cases were more likely than controls to report past occupational exposures to paints, insecticides and organophosphates, and telomere lengths were shorter among those exposed to these substances than those who were not.

4. Flow-FISH analysis showed that MDS cases had shorter telomere lengths in both CD15+ neutrophils and and CD19+ lymphocytes.
Kind regards
Birgitta-A
Reply With Quote
  #5  
Old Thu Mar 10, 2011, 03:10 PM
Lisa V Lisa V is offline
Member
 
Join Date: Aug 2006
Location: Waimanalo, Hawaii
Posts: 401
This is still fairly new research. The first any of us heard about it was in 2005, and then only related to AA. The thinking at that point was that people who had shortened telomeres were less likely to respond to IST (ATG/cyclo), so it might be better for them to go directly to transplant. That is the only practical application I can think of. The test is not routinely done, and we didn't ask for it because by that point we already knew that Ken had responded to IST. The relationship to relapse is news to me, as is the MDS connection.
__________________
-Lisa, husband Ken age 60 dx SAA 7/04, dx hypo MDS 1/06 w/finding of trisomy 8; 2 ATGs, partial remission, still using cyclosporine
Reply With Quote
  #6  
Old Wed Jan 18, 2012, 02:18 PM
dfantle dfantle is offline
Member
 
Join Date: Jan 2012
Location: bellevue, wa
Posts: 150
Yes, I was tested for this November 2011 at the National Institutes of health (NIH). The results were negative, however had it been positive it might have explained the cause of my aplastic anemia.

Best, Dena

Quote:
Originally Posted by edithr View Post
Anybody here ever had this test? Or hear of it?

http://www.nih.gov/researchmatters/s...2010anemia.htm

Thanks.
Reply With Quote
  #7  
Old Thu Jan 19, 2012, 07:16 PM
edithr edithr is offline
Member
 
Join Date: Feb 2011
Location: 30 mi West of Cleveland
Posts: 86
I should update. Eric was later tested at repeatdiagnostics.com in Canada. We had to jump through hoops with our insurance, but whatever.

Three of his telomeres are in the 1st percentile, the other three are in the 10th percentile. There was some talk that he might have Dyskeratosis Congenita, but they decided he did not. DC patients have ALL telomeres well below the first percentile.

Many aplastic patients have shortened telomeres.
__________________
Edith, mom to Eric, dx 2/11 at age 15 with SAA, began ATG/CsA 3/11, switched to Tacrolimis 8/11, off all meds 9/11 and is now considered to have bone marrow failure not otherwise specified.
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Questions about agent use and length Fordad MDS 11 Sun Jan 15, 2017 11:26 AM
Vidaza Cycle length anangel8 Drugs and Drug Treatments 2 Tue Oct 8, 2013 10:25 PM
length of doner stay in hosp. Iron Mike Tell Your Story 2 Mon Apr 9, 2012 03:10 PM
Length of time for test results - help please ellenemk MDS 3 Mon Jun 27, 2011 03:08 PM
Vidaza: length of interval between cycles? Va-L Drugs and Drug Treatments 0 Wed Oct 27, 2010 04:37 PM


All times are GMT -4. The time now is 05:04 PM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright © 2006-2020 Marrowforums.org