ASH 2010 Iron Overload Accelerates Development of Leukaemia - Mouse Model
122 Iron Overload Accelerates Development of Leukaemia: Evidence From a Mouse Model
Transfusion related iron overload is common in MDS and causes many problems.
Citation: "Clinical data have suggested iron also causes haematopoietic toxicity in MDS since iron chelation can lead to dramatic reduction in transfusion requirements and in large registry studies leukaemia-free survival is inversely related to serum ferritin."
These observations had previously not been supported by data. In a mouse model this study leads to the conclusion that" iron is mutagenic in haematopoietic cells and can promote progression of a pre-leukaemic state to frank AML."
Margarete, 54, living in Vienna, Austria,
MDS/AML M2, diagnosed 9/2007, then Chemos, aSZT 4/2008, chronic GVHD
Last edited by akita : Sat Dec 11, 2010 at 04:45 PM.
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