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Bone Marrow Failure Causes, treatment approaches, terminology, related diseases

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Old Thu May 31, 2018, 03:22 PM
silvers silvers is offline
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Location: Winterville, NC
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Severe hypocellularity with normal PBC

Hello, I am new here. My recent BMB showed severe hypocellular bone marrow 5-8 percent, but normal peripheral blood counts. The symptoms that led me to have the BMB performed have resolved. I have a history of polycythemia Vera which you would expect hypercellularity. I am being treated with a targeted therapy drug, which Dr does not believe to be the cause. My additional labs ordered to r/o source have all came back negative. I have a great hematologist which is waiting and watching now for changes in peripheral blood counts. Has anyone else experienced this.
Thanks In Advance, Sue
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Old Sat Jun 9, 2018, 01:22 PM
Hopeful Hopeful is offline
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Hi silvers,

The bone marrow can be patchy - some sections with many cells and some with few. Perhaps that is what happened here??? If you are very concerned or your counts start dropping, request another BMB to see if the cellularity results are different.
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52 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. Tried slow cyclosporine taper over 4+ years. Platelets fell, so back on cyclosporine. Trisomy 6 clone in 5% of cells.
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Old Thu Jun 21, 2018, 01:39 AM
silvers silvers is offline
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Hello Hopeful,
Thank you so much for your response.
A physician I work for made the same suggestion to me.
I wish you continued progress with your treatment plan.
Take care
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