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AA Aplastic anemia

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Old Sun Jun 24, 2018, 07:07 AM
Asingh Asingh is offline
Join Date: Jun 2018
Location: Delhi india
Posts: 1
Unrelated hla matched donor transplant vs atg+cyclosporine .

Diagnosed aplastic anemia 1 month back at 39 yrs age , my brother and sister are not hla matching with me . Sent for high resolution hla matching to find unrelated hla match in DATRI and other bone marrow registry .
If. I get a match which one is better unrelated matched transplant or atg + ciclisporin.
What is current treatment for 39yrs old newly diagnosed aplastic anemia otherwise healthy ?
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Old Sun Jun 24, 2018, 02:07 PM
Hopeful Hopeful is offline
Join Date: Jan 2009
Location: California, USA
Posts: 697
Hi Asignh,

It is my understanding that ATG+Cyclosporine is still the first-line treatment for someone your age with no matched sibling donor.

Here is a recent article on this:
52 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. Tried slow cyclosporine taper over 4+ years. Platelets fell, so back on cyclosporine. Trisomy 6 clone in 5% of cells.
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Old Mon Jun 25, 2018, 06:25 PM
evansmom evansmom is offline
Join Date: Nov 2007
Location: Ontario, Canada
Posts: 203
I believe Hopeful is correct.
Nicole, mom to Evan (20); diagnosed SAA November 2007, hATG mid-November 2007, no response after 6 months, unrelated 9/10 BMT June 2008, no GVH, health completely restored thanks to our beloved donor Bryan from Tennessee.

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