Home         Forums  

Go Back   Marrowforums > Practical Issues > Questions and Answers
Register FAQ Search Today's Posts Mark Forums Read

Questions and Answers Not sure where to post a question? Post it here.

Reply
 
Thread Tools Search this Thread
  #1  
Old Thu Dec 9, 2010, 02:57 AM
lindy lindy is offline
Member
 
Join Date: Nov 2010
Posts: 48
low platelets & MPV

I have low platelets but notice that my mean platelet volume (MPV) is high.
Does anyone has the same situation? Why is platelet count low when volume is high? Is the any relationship between the two?
Appreciate any help. Thanks.

Platelet = 103
MPV = 9.8
__________________
Lindy 56, low platelets, thrombocytopenia dx 2009, in watch & wait mode.
Reply With Quote
  #2  
Old Thu Dec 9, 2010, 12:01 PM
Neil Cuadra Neil Cuadra is offline
Owner
 
Join Date: Jul 2006
Location: Los Angeles, California
Posts: 2,553
MPV is a measure of the size of your platelets, rather than the number of your platelets.

Platelets are larger when they are first formed, so a patient with increased platelet production (lots of new platelets) or short platelet lifespans (few old platelets) would presumably have elevated MPV. A high value can be a sign of ITP (idiopathic thrombocytopenic purpura), while a low MPV is common in aplastic anemia patients.

Did your doctor or lab tell you that your MPV of 9.8 is high? From the reference ranges I've seen, you're within the normal range but on the high end within that range. Some labs consider "high" to mean anything over 10 or 11, but others may consider an MPV up to 15 to be in the normal range. In any case, the value may fluctuate from test to test so you'd want to check test results over time, not rely on a single CBC.

Given your low platelet count, it would be worth asking your doctor if your MPV measurement sheds light on your condition. If you do, please share with us what you learn!
Reply With Quote
  #3  
Old Sat Dec 11, 2010, 08:42 AM
lindy lindy is offline
Member
 
Join Date: Nov 2010
Posts: 48
Thanks Neil for your helpful comments.

I'm back from the hospital after seeing the haematologist.
My CBC is about the same as previous. Platelets still low.

I check with him & he said my MPV of 9.8 is considered high as the normal range here is usually 7-8+.
Neil, you're right, he explained about MPV & said my case at this moment is ITP. (But doesn't rule out the possibility of MDS later on)
He mentioned that the polyclinic had tested me early this year for Hepatitis & SLE which were negative. (I thought they did only CBC & blood smear)
He told me to watch out for any new symptons, then he may consider doing BMB.
If my platelets continue to remain low for another year or two he may review the need for BMB even without new symptons.

Will go back to him for another CBC next year.
__________________
Lindy 56, low platelets, thrombocytopenia dx 2009, in watch & wait mode.
Reply With Quote
  #4  
Old Sun Dec 12, 2010, 03:42 PM
akita akita is offline
Member
 
Join Date: Nov 2010
Posts: 110
ASH 2010 Two screening tests for immune thrombocytopenia component in MDS-Patients

Hi Lindy,

This study -

http://ash.confex.com/ash/2010/webpr...aper34476.html | Author

2943 Platelet-Associated IgG May Be Associated with Thrombocytopenia In Patients with Myelodysplastic Syndromes

- found out that MPV was significantly higher in patients with platelet count < 100 x109/L( median, min-max: 9.38, 6.9-23.1 vs *8.46, 4.88-12.83 ; p<0.001, Wilcoxon rank sum test).

Your doctor can relatively easily find out if you belong to the group of MDS-patients where immune destruction of platelets could be an additional factor in the genesis of thrombocytopenia.

"Thus, we propose that a combination of a simple index as MPV and a highly sensitive and easy to perform screening test for PAIgG as PIFT could be applied to select a subset of MDS patients in which we would be able to prevent the overuse of unnecessary platelet transfusions and who could be candidates for an immunosuppressive therapeutic approach. "

ITP could be an approach helping you to get medicaments like NPlate, but the actual studies seem not promising the optimum of safety for MDS-patients.

Hope i could help.

Regards,

Margarete
__________________
Margarete, 54, living in Vienna, Austria,
MDS/AML M2, diagnosed 9/2007, then Chemos, aSZT 4/2008, chronic GVHD
Reply With Quote
  #5  
Old Mon Dec 13, 2010, 04:55 AM
lindy lindy is offline
Member
 
Join Date: Nov 2010
Posts: 48
Thank you akita for your help.

Trying hard to understand all the info available here.

Thanks again.
__________________
Lindy 56, low platelets, thrombocytopenia dx 2009, in watch & wait mode.
Reply With Quote
  #6  
Old Mon Dec 13, 2010, 08:23 AM
Dick S Dick S is offline
Member
 
Join Date: Jan 2008
Location: Florida
Posts: 189
On my chart, MPV shows a min/max of 9 to 12.3 and mine consistantly run right around 12, much higher than yours and they still haven't started any treatment on me.
These limits are VA/Medicare figures.
__________________
Dick S, diagnosed Feb. 2008 with MDS. Last BMB April 2016. New diagnosis is CMML stage 1.
Reply With Quote
  #7  
Old Mon Dec 13, 2010, 04:34 PM
akita akita is offline
Member
 
Join Date: Nov 2010
Posts: 110
Hi Lindy,

thank you for your interest. i have read the article again and also for me it is hard to understand, over all the practical use of the study: Is this mainly for Brazilia, to find out the immune thrombocytopenic MDs-patients from diagnosis on? If you have already big problems with your trombocytopenia and immune reactions to thrombo-concentrates, there is perhaps no doubt that you belong to the immune thrombozythopenic group..But the screening could ad least help patients at diagnosis helping to get no useless treatments.

Regards,

Margarete
__________________
Margarete, 54, living in Vienna, Austria,
MDS/AML M2, diagnosed 9/2007, then Chemos, aSZT 4/2008, chronic GVHD
Reply With Quote
  #8  
Old Tue Dec 14, 2010, 08:23 PM
lindy lindy is offline
Member
 
Join Date: Nov 2010
Posts: 48
@ akita -I'm seeing doc in a public clinic/hospital & they usually don't support any tests unless really necessary due to cost. Anyway thanks for the info.

@Dick S - sometimes it may be better not to start any treatment which may make the situation worse. You're possibly right, funding is always a issue. At least you have your own personal insurance cover. I only have a basic low public cover that most citizens get.
__________________
Lindy 56, low platelets, thrombocytopenia dx 2009, in watch & wait mode.
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
High MPV count low platelets carolyn Bone Marrow Failure 2 Tue Oct 22, 2013 08:10 PM
Normal MPV but low platelets TASHMAC Questions and Answers 2 Thu Oct 25, 2012 03:24 PM
Low platelets (since 04) and low mpv with bleeding DebJM78 Tell Your Story 22 Tue Aug 28, 2012 05:39 PM
cmml treatment low platelets mcgill54 Drugs and Drug Treatments 41 Wed Apr 20, 2011 02:28 PM
Eltrombopag for low platelets will perhaps be approved June 19 Birgitta-A Drugs and Drug Treatments 0 Sat May 31, 2008 03:08 PM


All times are GMT -4. The time now is 02:43 PM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright © 2006-2020 Marrowforums.org