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Old Mon Nov 24, 2014, 08:46 PM
apantoja apantoja is offline
Join Date: Oct 2014
Location: Colombia
Posts: 5
Question Missing Vidaza due to Xmas and New Years eve. How bad is that?

My mother is starting her 1st cycle today. She is on a 5-2-2 schedule.
Her next cycle should start on the 22nd of Decemberbut we were told the place where she receives the aza treatment is closed in the following days as they are bank holidays (they don't open on sat or Sundays)

24th December
25th December

31st December
1st January

5th January
6th January

They suggested not to start the aza cycles on Thursdays or Fridays therefore they might suggest to start her 2nd cycle on the 7th of January or even the 12th of January.
How bad can it be to delay her 2nd cycle by 3weeks?
My mother 72 has RCMD , Hb between 4.7 and 10.4 (after transfusions). Platelets 42k. Started 1st cycle of Azacitidine 5-2-2 in November 24th. WBC 4.8
blasts 4%. Intermediate-1 risk classification of MDS
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Old Tue Nov 25, 2014, 12:30 AM
DanL DanL is offline
Join Date: Dec 2010
Location: Denver, CO
Posts: 587
dose delays are pretty common with vidaza and decitabine, but the impact of delays not due to marrow suppression doesn't have a lot of clinical data behind it as far as I have seen, so knowing the impact of a 3 week delay is very hard to predict. My personal preference would be to see if the office you are working with had any partner clinics that you could work with for the second cycle to prevent further delay, but I am not a doctor, nor am I an expert on Vidaza, but my preference is to work from the known rather than the unknown when it makes sense.
MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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Old Tue Nov 25, 2014, 09:38 AM
bailie bailie is offline
Join Date: Dec 2013
Location: McMinnville,OR
Posts: 825
I had a similar situation when I started Vidaza last year at this time. I called Celgene and they wouldn't tell me anything except their programmed response that Vidaza was approved for treatment of seven consecutive days followed by a 21 day break. Since the location I received my Vidaza shots was only open Monday through Friday, I went to a different location for my weekend and holiday shots. This was similar to Dan's suggestion.
age 70, dx RAEB-2 on 11-26-2013 w/11% blasts. 8 cycles Vidaza 3w/Revlimid. SCT 8/15/2014, relapsed@Day+210 (AML). Now(SCT-Day+1005). Prepping w/ 10 days Dacogen for DLI on 6/9/2017.
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