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MDS Myelodysplastic syndromes

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Old Wed May 14, 2014, 11:16 PM
kyis kyis is offline
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Join Date: Jun 2013
Location: Marin, California
Posts: 56
What does extremely hypocellular mean?

I just got this report, but have not heard from my dr. yet
I've been up to 9% blasts and have always been hypocellular.
Last bmb said 5-30%.
So is extremely mean less than 5%?
Whats all that CD stuff.
I still feel fine, working and have had no treatments.
Are my blasts now 1% and does low cellularity effect that %?

Thanks for any answers anyone may have!



FINAL PATHOLOGIC DIAGNOSIS
BONE MARROW: NONLYMPHOID BLASTS, 1% OF TOTAL EVENTS, EXTREMELY HYPOCELLULAR SPECIMEN, see comment.

Comment
Smears prepared from material submitted for flow are extremely
hypocellular. The specimen may not be representative. By flow,
nonlymphoid blasts account for approximately 1% of total events.
CD2 is essentially negative in the current study. The numbers of
granulocytes and monocytes are extremely low. Correlation with
other clinical studies is suggested for definitive diagnosis.
Antibody to CD45 was used for gating.
2 smears reviewed for this study.
Flow Cytometry Findings
Sample viability (by dye exclusion): 99%
Gating Strategy: CD45 versus side scatter.
A population of CD34 positive non-lymphoid blasts accounts for
approximately 1% of events.
Positive for: CD33 (dim), CD13, CD34, CD117, and HLA-DR.
Negative for: CD3, CD4, CD8, CD56, CD5, CD7, CD2, CD10, CD14,
CD15, CD61, CD19, CD20, kappa, and lambda.

Clinical History
52 M RAEB-1, repeat bone marrow to assess for progression.

GENETICS CANCER CHROMOSOME ANALYSIS

Indication: MDS/PRELEUKEMIA (MYELODYSPLASTIC S Status: Rule out
Indication: THROMBOCYTOPENIA Status: Affected
Other Reasons: RAEB-1, NEUTROPENIA
RESULT
Method: GTW
Number of cells/colonies: 20 Band Level: 400

Karyotype: 46,XY[15]
*INTERPRETATION*
Normal male karyotype. The population of cells analyzed
did NOT confirm that a clonal chromosome abnormality
is present; however, it does not exclude the possibility
that a neoplastic process exists.
NOTE: Number of cells counted: 20; Number of cells analyzed:
20; number of karyograms prepared: 2
__________________
Male 56, MDS 2008, pre SCT Hypocellular 5-30%, Normal Cytogenetics. WBC 500, anc 45, Blasts 15%, Platelets 45, HGB 7, RBCC 1.71, HCT 20.5, MCV 120. Became Transfusion dependent 3/2016. 5 cycles VIdaza started 3/14/16 which reduced Blast counts. . Marrow Transplant 9/1/16, Hereditary MDS/AML.
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