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Old Wed Aug 27, 2014, 03:16 PM
Marrowforums Marrowforums is offline
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Promacta Approved for U.S. Treatment of Severe Aplastic Anemia

On August 26, 2014, the U.S. Food and Drug Administration approved use of Promacta (eltrombopag) for treatment of severe aplastic anemia when the patient has had an insufficient response to immunosuppressive therapy such as ATG, and when the patient is not a transplant candidate.

Promacta increases production of blood cells by inducing stem cell proliferation and differentiation in the bone marrow. It is taken orally, once daily. In a trial, about 40 percent of patients who had not responded to immunosuppression had clinically significant responses to Promacta. Some patients were able to discontinue taking Promacta while maintaining their blood counts across all three blood lines.

Promacta is generally well tolerated although one-fifth to one-third of patients may experience nausea, fatigue, cough, diarrhea, or headaches.

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Old Wed Aug 27, 2014, 04:14 PM
Alcof Alcof is offline
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That is brilliant news!

Thank you so much for posting this and keeping us on top of where we are with this new hope...
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Father 72 has been diagnosed VSAA June 2014, was on cyclosporine as first treatment 06/2014 - 09/2014. 8 weeks after diagnosis doctor believe he would not survive ATG Treatment. GCSF 3 weeks Aug 2014 Currently on Eltrombopag 09/14 Danazol 25/08/14.
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Old Thu Aug 28, 2014, 02:07 PM
Birgitta-A Birgitta-A is offline
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Thumbs up Promacta

Very good news!
Kind regards
Birgitta-A
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