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Old Wed Apr 25, 2018, 03:01 PM
Marlene Marlene is offline
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Arthritis drug for GVHD

An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research shows.

https://www.sciencedaily.com/release...0424184126.htm
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Old Wed Apr 25, 2018, 04:31 PM
Neil Cuadra Neil Cuadra is offline
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It's always interesting when a drug for one disease is found to be useful for other diseases.

They aren't sure how this JAK inhibitors (baricitinib) helps with GVHD, but the article shares one theory: that it keeps donor T cells circulating in the bloodstream and away from vital organs.
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Old Thu Apr 26, 2018, 11:13 AM
Marlene Marlene is offline
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If memory serves me correctly, Solaris, now used for PNH, was also being developed for RA but failed to treat it. It was a unexpected breakthrough for the treatment of PNH though.
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