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Transplants Bone marrow and stem cell transplantation

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  #1  
Old Tue Aug 30, 2011, 08:56 PM
kathrnclark kathrnclark is offline
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Location: Los Angeles, CA
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Aplastic Anemia - BMT Pre-Treatment Drugs

Hi All!

I was given a calendar of my protocol today for my BMT and am wondering if other transplantees out there have had any advice or experience with these particular drugs (I also posted this question on the "AA" forum:

Day -5 - Fludarabine
Day -4 - Fludarabine/ATG
Day -3 - Fludarabine/ATG/Cytoxan (re-start cyclosporin)
Day -2 - Fludarabine/ATG/Cytoxan
Day -1 - Total Body Radiation
Day Zero - TRANSPLANT!!! - WOO WOO!!
Day 1 - Methotrexate
Day 3 - Methotrexate
Day 6 - Methotrexate
Day 11 - Methotrexate

Thanks!!
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www.aplasticanemiablog.com
30 - Severe Aplastic Anemia - Diagnosed January 2011
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  #2  
Old Wed Aug 31, 2011, 12:40 AM
Ruth Cuadra Ruth Cuadra is offline
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Katherine,

My pre-transplant regimen was very different from yours, but with the exception of Fludarabine, I had the same stuff:
Day -7 through Day -4 - Total Body Irradiation
Day -3 and Day -2 - Cytoxan
Day -1 - Rest (no treatments)
Day 0 - Transplant

I was very worried about the cytoxan because of all the ugly things we know about what chemotherapy does to people. Some people breeze through radiation and then get quite sick from chemo. I was the opposite, very sick during TBI treatment, but fine during chemo. The amount of radiation you will have is substantially less that what I got -- in part because the protocols have continued to improve and less harsh doses are possible.

I also had Methotrexate on a slightly different schedule, but I don't remember any particular side effects of that.

My story is posted here. Don't hesitate to ask me about any of it.

Regards,
Ruth
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  #3  
Old Wed Aug 31, 2011, 08:56 PM
evansmom evansmom is offline
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My son's conditioning was exactly the same as yours, except, due to his younger age, he did not have radiation.

He sailed through transplant and recovered quickly with no GVH whatsoever.

I wish you all the best.
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Nicole, mom to Evan (20); diagnosed SAA November 2007, hATG mid-November 2007, no response after 6 months, unrelated 9/10 BMT June 2008, no GVH, health completely restored thanks to our beloved donor Bryan from Tennessee.

www.caringbridge.org/visit/evanmacneil
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  #4  
Old Thu Sep 1, 2011, 02:42 PM
kathrnclark kathrnclark is offline
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RE: BMT Medications

Quote:
Originally Posted by evansmom View Post
My son's conditioning was exactly the same as yours, except, due to his younger age, he did not have radiation.

He sailed through transplant and recovered quickly with no GVH whatsoever.

I wish you all the best.
Thank you so much! This is really encouraging - I appreciate it!!!!
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30 - Severe Aplastic Anemia - Diagnosed January 2011
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