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AA Aplastic anemia

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Old Fri Oct 30, 2015, 04:29 PM
TASHMAC TASHMAC is offline
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Join Date: Oct 2012
Location: Cayman Islands
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Rabbit ATG and Lymphocytes???

I had my second round of ATG in May of this year and this time had rabbit. Unfortunately I have not responded as quickly or as well as I did to the horse ATG I had in November of 2012.

I am now on cyclosporine of 225mg per day and 5mg of prednisone every other day.

The reason for this post is to ask about other peoples lymphocytes post rabbit ATG. I was warned that my lymphocytes may take at least 6 months to recover and as I am now edging ever closer to the 6 month mark and have seen very little improvement with my lymphocytes I am interested to know whether people have seen their lymphocytes improve 6+ months post rabbit ATG.

My other counts are still pretty average, Plts hovering between 50 and 65, WBC between 1.5 and 2.2, ANC between 0.9 and 1.5, HGB around 8.9.

I have seen very little change in my counts since mid July of this year. My WBC has however fallen but I think in part this is due to the fact that I have stopped taking prednisone.
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Old Mon Nov 2, 2015, 01:55 PM
Hopeful Hopeful is offline
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Hi TASHMAC,

From what I have read, it is pretty common to have a low ALC even 6 months after Rabbit ALG. However, they never state when the ALC starts risings again in the research reports :-/

Do you still have hemolysis and an elevated LDH? There is an upcoming live webcast from the AA&MDSIF conference in Florida on November 14th that will be focusing on PNH. Here is the link to register:

http://webcast.eventtechnologysoluti...gistration.asp
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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Old Tue Nov 3, 2015, 09:35 AM
TASHMAC TASHMAC is offline
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Yes still seem to be suffering from hemolysis as retic count still on the high side but hgb not improving. LDH is only slightly elevated. MCV is pretty high though.
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