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#1
Mon Dec 8, 2014, 09:52 AM
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Why would lymphocyte levels be low
From my understanding of MDS, the reason for the cytopenias is a defect in the myeloid blood line that produces red blood cells, platelets, and some of the white blood cells (basophils, eosinophils, monocytes, and neutrophils). I also understood that the lymphoid line created the lymphocytes (B-cells, T-cells, and NK cells). My question is if my problem is in the myeloid line why would I also have consistently low lymphocyte levels (usually around 0.8). Any ideas would be greatly appreciated.
Hoping everyone on the forum has a happy holiday season!!  Data
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Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016. 
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#2
Mon Dec 8, 2014, 12:20 PM
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Here's what I think I know about lymphocyte count and MDS. The two major components of your white blood cell count are neutrophils and lymphocytes, at least when your blood count is normal. It is fairly common for the lymphocyte count to be depressed with MDS as lymphocytes are produced in the marrow along with neutrophils, monocytes, eosonophils, etc. Lymphocytes start off as a generic white blood cell, then migrate to the Thymus to mature and differentiate. If the factory (marrow) isn't producing enough white blood cells, or defective white blood cells, then your lymphocyte count may have problems along with your neutrophil count.
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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#3
Mon Dec 8, 2014, 11:56 PM
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Not sure why exactly but I've had low lymphocytes since my AA days. Not sure on their impact on me really because I've always had a low count. I've started having infection issues recently, not sure why. My lymphocytes are still the same as usual.
So hmmmm...don't know
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Julie (38yrs); dx AA 1996 & treated w/ATG, cyclosporine & G-CSF; 2010 dx int-1 secondary MDS, low platelets, on prevention antibiotics, fevers of unknown origin, MUD found for BMT when the time is right, which is now! MDS transformed to AML after many infections.
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#4
Tue Dec 9, 2014, 12:36 AM
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Like DanL my impression is that if the WCC is low then normally the lymphocyte levels would be contributing to that. (My lymphocytes average 0.4 and have been at that level for years).
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Dx MDS RAEB 10% blasts + hypogammaglobulinemia, Sep 2011. Jan 2012 BMB - blasts down to 2% w/out treatment so BMT cancelled. Re-diagnosis RCMD. Watch and wait from Feb 2012. IVIg 5-weekly. New diagnosis Oct 2019 AML 23% blasts in marrow, 10% blasts in peripheral blood.
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#6
Tue Dec 9, 2014, 12:26 PM
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Thanks folks
Thanks for all the comments.
I started Epogen Alfa today. Have a Happy Holiday!!! Data
__________________
Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016. Last edited by Data : Wed Dec 10, 2014 at 08:41 AM. Reason: Corrected name f drug
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#7
Tue Dec 9, 2014, 08:28 PM
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Good you are able to get some help Data. Seasons greetings to you all too!
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Dx MDS RAEB 10% blasts + hypogammaglobulinemia, Sep 2011. Jan 2012 BMB - blasts down to 2% w/out treatment so BMT cancelled. Re-diagnosis RCMD. Watch and wait from Feb 2012. IVIg 5-weekly. New diagnosis Oct 2019 AML 23% blasts in marrow, 10% blasts in peripheral blood.
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#8
Thu Dec 11, 2014, 01:32 AM
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Hi Data, is that Gcsf you've started? All the best xo
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Julie (38yrs); dx AA 1996 & treated w/ATG, cyclosporine & G-CSF; 2010 dx int-1 secondary MDS, low platelets, on prevention antibiotics, fevers of unknown origin, MUD found for BMT when the time is right, which is now! MDS transformed to AML after many infections.
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#9
Thu Dec 11, 2014, 08:37 AM
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Epogen
Quote:
As far as I know the GCSFs are supposed to stimulate the growth of white blood cells, specifically neutrophils. The Epogen I started is to stimulate the growth of the red blood cells and improve my hemoglobin level. I believe they are given together sometimes but I am just on the Epogen. Good luck with you BMT!! Happy holidays Data
__________________
Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
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