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  #1  
Old Sat Aug 6, 2011, 04:36 AM
pvinod pvinod is offline
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Danazol side effect

Hi All,

My daughter prescribed Danazol 50mg 2 times a day. but she face side effect like reduce platelet count. She is suffering from AA and we transfuse platelet count every 7 days, but from when she start taking danazol every 3 days she need platelet.

we ask doctor but they are not ready to believe that due to Danazol platelet count decrease?

can anyone experience like this?

Regards,
Vinod father of Kavya , AA, ATG on Dec-2010, still not response, 0.5 ml CsA , Femal
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Kavya; my daughter age 4.5; diagnosed AA 2010; treated with ATG in December 2010; currently on cyclosporine; 6 month over for ATg but still transfusion dependent;
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  #2  
Old Sat Aug 6, 2011, 10:56 AM
Neil Cuadra Neil Cuadra is offline
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Kavya,

I'm sorry that your daughter hasn't yet responded to ATG.

Low platelets is not an established side effects of Danazol.

There have been individual reports of decreased platelets by people taking Danazol but it's never been found that Danazol was the cause. There have also been individual reports of increased platelets.

I think that means that the answer to your question is that it's unlikely but possible.

You didn't say why your daughter is taking Danazol, i.e., for angioedema or another condition. Depending on the reason, her doctors could consider other medicine that treats the same condition. Each medicine has its own benefits, risks, and possible side effects.
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Old Tue Sep 27, 2011, 07:03 AM
pvinod pvinod is offline
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Hi Neil Cuadra,

Thanks. sorry for late reply.

she is prescribed for danazol for same Aplastic Anemia. Doctor prescribed cyclosprine, danazol and folic acid.

so danazol not used in AA? can danazol help in increase the chances of response after ATG? In US doctor not use danazol? Please guide me.


Regards,
Vinod
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Kavya; my daughter age 4.5; diagnosed AA 2010; treated with ATG in December 2010; currently on cyclosporine; 6 month over for ATg but still transfusion dependent;
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  #4  
Old Tue Sep 27, 2011, 08:47 AM
Marlene Marlene is offline
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Danazol has been used by others on this forum. It's helped some but not others.

If you do a search on this site for danazol, it will bring up the post that discuss it. Here's one where it helped the reitc/red cells but did adversely affect the platelets. It could be the dose is too high.

http://forums.marrowforums.org/showt...hlight=danazol
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of January 2017, FE is 233, HGB 11.7, WBC 5.1/ANC 4.0, Plts 146K.
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Old Wed Sep 28, 2011, 08:27 AM
pvinod pvinod is offline
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Thanks Marlene,

yes, my daughter have same, when she start danazol, platelets transfusion become more.

so we had stopped it. She does not take it longer time, so cannot judje, it help in rectic\red cell or not.

currently we are giving just cyclosporine and folic acid.

Thanks again.
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Kavya; my daughter age 4.5; diagnosed AA 2010; treated with ATG in December 2010; currently on cyclosporine; 6 month over for ATg but still transfusion dependent;
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