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#1
Wed Jul 19, 2017, 08:28 AM
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2nd Cancer after Treatment for MDS
Has anyone been diagnosed with a second type of cancer or had a previous cancer return after treatment for MDS?
The reason I am asking is when I was considering the stem cell transplant for my MDS I was warned that there was a remote chance that the conditioning (myeloablative) could cause a second cancer or cause a previous cancer to return. I should have paid more attention. I was treated for prostate cancer in 2013 with high dose rate brachytherapy. My SCT was in April of 2016. My prostate cancer has returned and is metastatic. Just wondering if this has happened to anyone else. Thanks Data
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Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016. 
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#2
Wed Jul 19, 2017, 12:28 PM
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I am sorry to read this, Data. You have come so far!
My thoughts are with you. Remember that you are a fighter and keep fighting!
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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#3
Wed Jul 19, 2017, 07:22 PM
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Thanks
You are young to have so many of these problems. Maybe being younger will help your body fight the little monsters.
What is funny in my case is when I got the radiation for prostate cancer they said it could cause other cancers. Similar to what they said when I got the transplant. Several doctors have suggested the radiation for prostate cancer could be the cause of my MDS. Now the treatment for MDS may have brought my prostate cancer full circle. Best wishes to you!!! Data
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Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
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#4
Thu Jul 20, 2017, 05:01 AM
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I'm really sorry to hear this news, Data. You've been such a positive contributor to this forum. Best wishes for whatever you decide to do next. I'll be watching for your posts.
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Dx MDS RAEB 10% blasts + hypogammaglobulinemia, Sep 2011. Jan 2012 BMB - blasts down to 2% w/out treatment so BMT cancelled. Re-diagnosis RCMD. Watch and wait from Feb 2012. IVIg 5-weekly. New diagnosis Oct 2019 AML 23% blasts in marrow, 10% blasts in peripheral blood.
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#5
Sun Jul 23, 2017, 06:34 AM
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Yeah I think any high dose chemo can unfortunatly increase likelyhood of cancer. You will beat this though!! Good luck, stay positive.
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Now 30yr old. Diagnosed AML dec 2015 (Most likely MDS prior). Trisomy 6. Runx1 mutation also. Had induction and consolidation chemo. Marrow failure ++ so SCT on 21st of March with MUD. Married with a 1yr old!
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#6
Wed Jul 26, 2017, 06:23 PM
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Revised prognosis
All,
Thanks for all the well wishes!!! On Friday my PSA was 7.4 (down from a high of 20). A ENT doctor ruled out the metastasis that was indicated in the PET Scan. The urologist that originally said my prostate cancer was “aggressive and metastatic” revised his opinion to “contained within the prostate”. I talked to a different urologist today (the original one was out sick today) and we decided to check the PSA again in a 3 months and go from there. Cheers Data
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Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
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#7
Thu Jul 27, 2017, 02:50 AM
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Thats great news!
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Now 30yr old. Diagnosed AML dec 2015 (Most likely MDS prior). Trisomy 6. Runx1 mutation also. Had induction and consolidation chemo. Marrow failure ++ so SCT on 21st of March with MUD. Married with a 1yr old!
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#8
Thu Jul 27, 2017, 03:15 PM
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Hope you continue to receive good news, Data!
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#9
Sun Jul 30, 2017, 12:57 AM
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Great news!! Hopefully the farther in time you get from your transplant, the stronger your immune system will be to keep the bad cells in check.
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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#10
Sun Jul 30, 2017, 08:35 PM
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That sounds more positive, data! May the good news continue ...
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Dx MDS RAEB 10% blasts + hypogammaglobulinemia, Sep 2011. Jan 2012 BMB - blasts down to 2% w/out treatment so BMT cancelled. Re-diagnosis RCMD. Watch and wait from Feb 2012. IVIg 5-weekly. New diagnosis Oct 2019 AML 23% blasts in marrow, 10% blasts in peripheral blood.
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#11
Wed Aug 2, 2017, 10:24 PM
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I'm so glad for the happy ending of this post!! I was quite sad to read the beginning.
Best wishes for continued good news!! 
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Husband (61) dx RAEB1 Apr 2015 after long term bad CBCs (first discovered Apr 2008 after an unknown infection had him hospitalized), currently on watch & wait with monthly bloodwork. Myeloid Gene Panel testing done Aug 2017, showed nothing worrisome. CEBPA mutation
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