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Drugs and Drug Treatments ATG, Cyclosporine, Revlimid, Vidaza, Dacogen, ...

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Old Tue Jan 3, 2017, 11:14 AM
disco3md disco3md is offline
Join Date: Aug 2016
Location: Washington DC
Posts: 6
ATG Treatment Expectations

My wife has serve AA. IN a clinical trial @ NIH. was on eltrombopag, didn't help her enough, so now she's starts the ATG Jan 9th.
I've heard/read number of things about the treatment. Wanted to get a feel about what to expect in terms of length of hospital stay? Reactions to the treatment? How soon will she start to feel better? Side effects ect?

thanks much
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Old Tue Jan 3, 2017, 02:17 PM
bailie bailie is offline
Join Date: Dec 2013
Location: McMinnville,OR
Posts: 825
You might start with the search feature for the forum in the above window and enter "ATG Treatment" in titles.
age 70, dx RAEB-2 on 11-26-2013 w/11% blasts. 8 cycles Vidaza 3w/Revlimid. SCT 8/15/2014, relapsed@Day+210 (AML). Now(SCT-Day+1005). Prepping w/ 10 days Dacogen for DLI on 6/9/2017.
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Old Tue Jan 3, 2017, 09:51 PM
DanL DanL is offline
Join Date: Dec 2010
Location: Denver, CO
Posts: 554
ATG side effects vary - definitely have your wife accept all pre-medications to help with them. I was treated with ATG prior to transplant, and it is the only thing that I have done that made me feel awful - severe flu-like symptoms that went away for me after two days. Here is a link from UPMC that lists the most common issues with treatment:


From what I have seen, results vary. A lot of people take cyclosporin with ATG treatment, especially for AA. Results can take anywhere from 1 month to 9 months to begin

Here is a pretty good article on AA treatments, side effects, and effectiveness:


This article gives more specifics about timeline:


Hope this info helps.

MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. No longer experiencing nor treating CGVHD. Working on fixing long-term side effects of AVN in hips and cataracts in eyes. Life is good!
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Old Wed Jan 4, 2017, 12:05 AM
Hopeful Hopeful is offline
Join Date: Jan 2009
Location: California, USA
Posts: 707
Hi disco3md,

Your wife will be in good hands at NIH, as I am sure that they have seen-it-all and know how to respond.

ATG is sometimes called shake-and-bake. That is what it was for me. I spiked a very high fever and had severe chills the first night. This was definitely the most miserable part of it all. It is also the riskiest part. If you can stay with your wife through that first night, I am sure that she will be grateful.

I felt pretty wiped out for the 2nd day and had painful swelling in my chest. By the third (?) or fourth day, I felt good enough to be walking around the hospital.

I had severe headaches when they administered the ATG. Some people will get severe leg cramps and a rash. Everyone is different.

How long she stays in the hospital will be dependent on whether she gets an infection or complication. She could be sent home within a week if all goes well. I felt like I was getting better almost immediately after ATG. It still took a while for me to get off transfusions, but at least I could feel that I was getting stronger instead of weaker.

Best of luck to her!
52 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. Tried slow cyclosporine taper over 4+ years. Platelets fell, so back on cyclosporine. Trisomy 6 clone in 5% of cells.
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Old Wed Jan 4, 2017, 02:49 AM
Neil Cuadra Neil Cuadra is offline
Join Date: Jul 2006
Location: Los Angeles, California
Posts: 2,473
Some patients, including my wife, have uncomfortable but temporary and non-life-threatening adverse reactions to the very first dose of ATG. For example, they may have allergic reactions, such as a rash. It seems that reactions differ from person to person, and the doctors can't predict them, but they can and do make adjustments to avoid reactions once they know how ATG affects you.

Some people are luckier and don't have unpleasant side effects.

The treatment takes only a few days, but recovery and resulting improvement can take months. It depends on the patient's disease and circumstances.
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Old Fri Jan 6, 2017, 01:36 PM
disco3md disco3md is offline
Join Date: Aug 2016
Location: Washington DC
Posts: 6
ATG Treament Feedback

thanks for all for the info on the replies really helped with my research
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