Home         Forums  

Go Back   Marrowforums > Bone Marrow Failure Diseases > MDS
Register FAQ Search Today's Posts Mark Forums Read

MDS Myelodysplastic syndromes

Reply
 
Thread Tools Search this Thread
  #1  
Old Wed Sep 12, 2012, 02:18 PM
donna j. donna j. is offline
Member
 
Join Date: Sep 2011
Location: long island, new york
Posts: 110
Question MDS following prior cancer chemo

Does anyone know what specific information from our testing, BMB, etc indicates the onset of MDS from being treated previously with chemo for a prior cancer? Robin Roberts assertion that she got this from her breast cancer chemo, makes me wonder if this is an educated leap by her doctors, or is there a marker or profile which tells the doctor that MDS has definitely come from the chemo?

thanks,

Donna
__________________
f68 MDS; abmt 1/12. ABO mismatch 11 mos. (70) transf. Ferr 3-5k. 8 phlebot. AGVHD to CGVHD. skin,eyes. lungs as of 10/13. muscle weakness &osteo long term steroids.photopheresis 2x wk as of 3-15.pred 20 eod,acyclovir, mepron, voriconazole, pantropazole, lisinopril, montelukast, anoro, azithromycin.
Reply With Quote
  #2  
Old Wed Sep 12, 2012, 08:29 PM
DanL DanL is offline
Member
 
Join Date: Dec 2010
Location: Denver, CO
Posts: 545
Donna,

This is a very good question.

Per the NIH:
Cases are attributed to prior therapy based on circumstantial evidence, such as the following: 1) presence of typical clonal cytogenetic abnormalities, 2) significant exposure to leukemogenic therapy (e.g., at least one cycle), and 3) sufficient latency from exposure to diagnosis of t-MDS (e.g., at least six months).

A high rate of MDS is found in patients who have had prior treatement that includes total body irradiation, alkalyting agents, or topoisomerase inhibitors.

Loss of material from chromosomes 5 and/or 7 is detectable in up to 70% of t-MDS/AML patients, often with other abnormalities in a complex karyotype. The same pattern of cytogenetic abnormalities occur in de novo MDS, but at much lower frequency.

The article that I picked this information up from is fairly complex, but does a good job of explaining what the rationale for believient that MDS is therapy related or not.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832708/

I hope this helps.
Dan
__________________
MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. No longer experiencing nor treating CGVHD. Working on fixing long-term side effects of AVN in hips and cataracts in eyes. Life is good!
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
MDS - VA assigns diagnostic code 7725 Tommy Daniels MDS 4 Sun Jan 22, 2017 03:51 PM
MDS from Chemo... No avaliable treatment?!? Jer MDS 2 Mon Jul 30, 2012 09:24 PM
Chemo treatment for MDS rdavidp MDS 4 Mon Apr 2, 2012 07:24 PM
MDS secondary to chemo from BMT? torbach1 MDS 1 Mon Jun 21, 2010 03:09 AM


All times are GMT -4. The time now is 01:42 AM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright 2006-2018 Marrowforums.org