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AA Aplastic anemia

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Old Tue Aug 2, 2011, 10:23 PM
KimO KimO is offline
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BMB Results -- Need help interpreting

Apparently our hemotologist is out until the middle of the month so I had to track down Shauna's BMB results from a week and a half ago. The nurse that read them yesterday said it indicated normal cellularity -- extra unexpected blessing -- but a 0.5% PNH clone. There was no clone noted in her original biopsy but her marrow was very empty so I suppose it's hard to say whether it was there and not noticed or has evolved. It apparently also indicates 1% blasts and unchanged from the last one. I don't remember them saying anything about blasts in the first one. Am I correct that blasts are just immature blood cells and that you would expect to see some even in a healthy marrow? Or is this something that should be watched even though it is a low number?
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Kim, mom to Shauna, SAA 10/2007 at age 19, ATG/Cyclosporine 12/2007, end cyclo 4/2009, relapse 8/2010, and 9/2012, counts recovered on cyclo alone 300 mg/day x 2.
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Old Wed Aug 3, 2011, 12:02 AM
Neil Cuadra Neil Cuadra is offline
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Yes you'd expect to see blast cells. It's normal to have up to 5% blasts in the marrow.
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Old Wed Aug 3, 2011, 01:01 PM
Hopeful Hopeful is offline
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Hi Kim,

Having a subclinical PNH clone is not too unusual in AA and should not be concerning. It is thought to be an indicator that the bone marrow failure is immune mediated.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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Old Wed Aug 3, 2011, 02:12 PM
KimO KimO is offline
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Thank you both for the quick replies. I thought I was a bit beyond getting worried about results but apparently not. You really helped to calm my fears!
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Kim, mom to Shauna, SAA 10/2007 at age 19, ATG/Cyclosporine 12/2007, end cyclo 4/2009, relapse 8/2010, and 9/2012, counts recovered on cyclo alone 300 mg/day x 2.
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