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AA Aplastic anemia

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  #1  
Old Wed Sep 16, 2015, 08:41 AM
James V James V is offline
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Hematocrit Variation

Hello,

My wife went through Horse ATG in early June 2015. As of 7/15/2015 her Hematocrit was at 24%. It steadily rose to 29% as of 8/21/2015, but has since fallen to 27% as of 9/15/2015. Her Retic count has also gone down from above normal levels, in the 6% range I believe, to 2.1%. Has anyone had their Hematocrit level drop after a steady rise post treatment? Can hematocrit and hemoglobin fluctuate if the treatment is still having a positive impact?

Thank you for sharing your experiences, this forum has helped us understand what to expect and what our expectations should be.

Last edited by James V : Wed Sep 16, 2015 at 10:37 AM.
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  #2  
Old Wed Sep 16, 2015, 12:02 PM
Hopeful Hopeful is offline
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Hi James V,

I tracked HGB vs HCT. My HGB increased rather rapidly after ATG and then fell. It took 8 months for me to slowly reach that post HGB level. If I look at my HCT, it bumped around until about the 6 month mark and then started a slow steady rise.

It is important to look for trends over the period of maybe 3 months. Try not to read too much into a single reading. Hydration levels, viruses, or lab inaccuracies are just a few variables that may affect a single result.

With regards to reticulocyte percentage, my doctor didn't check this often. When he did (after 3 months), it was usually in the 1.5 - 2.3% mark. When I was sick, it would be lower.

You could hypothesize that when your wife's reticulocyte count was high, it may have been because there was an intense immune attack going on that was rapidly destroying the RBCs. So the marrow was trying to keep up by cranking out the baby red cells. Post-ATG, you could argue that the major immune attack has been thwarted. Now the marrow still must slowly heal and rebuild. So retic count has normalized again.

Hope that helps! Try not to panic (always easier to say retrospectively)! You will learn patience with this disease
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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  #3  
Old Wed Sep 16, 2015, 01:48 PM
James V James V is offline
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Hopeful,

Thank you for taking the time to write a thoughtful response. This is a comfort to read, and remind me to remain patience.
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  #4  
Old Thu Sep 17, 2015, 09:53 AM
Marlene Marlene is offline
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Also, keep track of the absolute retic count. This is the actual number of reticulocytes. Percentages can be misleading.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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  #5  
Old Tue Oct 13, 2015, 07:28 PM
James V James V is offline
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Hi Marlene,

Thank you for the advice. I will look into the retic count.
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