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Drugs and Drug Treatments ATG, Cyclosporine, Revlimid, Vidaza, Dacogen, ...

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  #1  
Old Thu Feb 10, 2011, 07:23 PM
slip up 2 slip up 2 is offline
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Question revlimid
has anyone out there used revlimid with mild/moderate mds/montosmy 7.....thanks
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  #2  
Old Thu Apr 14, 2011, 01:30 PM
riccd2001 riccd2001 is offline
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FDA Safety Reassessment
Continuing Revlimid safety review...

http://www.mdsbeacon.com/news/2011/0...80%99s-safety/
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Ric: Low-risk MDS (blasts <4%); 4 cycles Revlimid no positive response; PRBC transfusion dependent; so far, 392'units' over 8 3/4 years; BMB #4 (15/04/01) shows evolution to AML (blasts 20-30%) 47,XY,del(5) (q22q35),+21[24][cp24]/46,XY(1).
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Old Thu Apr 14, 2011, 07:54 PM
slip up 2 slip up 2 is offline
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revlimid
thanks....saw that to-day....
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Old Fri Apr 15, 2011, 07:04 PM
riccd2001 riccd2001 is offline
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MDS Beacon has added more info. today...

http://www.mdsbeacon.com/news/2011/0...-it-all-about/
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Ric: Low-risk MDS (blasts <4%); 4 cycles Revlimid no positive response; PRBC transfusion dependent; so far, 392'units' over 8 3/4 years; BMB #4 (15/04/01) shows evolution to AML (blasts 20-30%) 47,XY,del(5) (q22q35),+21[24][cp24]/46,XY(1).
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Old Fri Apr 15, 2011, 07:50 PM
Greg H Greg H is offline
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25%?
Hi Slip Up!

The data I have seen suggests Revlimid response rates as high as 25% amongst folks without 5q -- those weren't necessarily Complete Remission, of course, but instead improved counts in one or more lines.

My Doc at The National Institutes of Health (US) mentioned to me that Monosomy 7 is a particularly stubborn abnormality -- hard to get a response and a strong possibility of progression to AML. Are you a candidate for transplant?

Take Care!

Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at www.greghankins.com
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