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#1
Wed Dec 8, 2010, 01:33 PM
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Cyclosporine and Cholesterol
Hi,
For the first time in my life, I have high LDL cholesterol. I eat healthy and am very physically active. After a quick google search, I learned that cyclosporine has been linked to increased LDL cholesterol in some people. Apparently, it binds to the bad LDL cholesterol and prevents the good HDL cholesterol from doing its job. For me, this resulted in a 30% increase in my bad (LDL) cholesterol levels! For you long term cyclosporine users out there, has anyone noticed a similar increase in their cholesterol? Does it just keep on going up with continued cyclosporine usage? Also, do the LDL levels come back down once the cyclosporine dosage decreases or stops?
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent 
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#2
Wed Dec 8, 2010, 07:14 PM
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Good question!
I have a PE coming up. I will find out my LDL level and I'll let the forum know.
I have been on 200mg twice a day for over 2 years and my HDL/LDL ratio has always been pretty good.
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Male, 56, dx Nov2006 VSAA (BMA:0%). Responded to ATG/CsA/Prednisone/Neupogen Dec 2006, but relapsed in June 2007. Counts are responding to using CsA 200mg bid alone since Jun 2008. Last PRBC tx: Jul 2008.
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#3
Wed Dec 8, 2010, 07:23 PM
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Mine got worse, but I thought it was because I wasn't getting the same type of exercise as I used to.
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Dallas, Texas - Age 81 - Pure Red Cell Aplasia began March 2005 - Tried IVIG - Then cyclosporine and prednisone. Then Danazol, was added. Then only Danazol . HG reached 16.3 March 2015. Taken off all meds. Facebook PRCA group https://www.facebook.com/groups/PureRedCellAplasia/
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#4
Wed Dec 8, 2010, 10:11 PM
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Quote:
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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