ASH 2010 Iron Overload results in deficient Hematopoiesis

[akita]

http://ash.confex.com/ash/2010/webpr...aper28958.html

4247 . "Increased Intracellular Concentration of Reactive Oxygen Species Mediated the Deficient Hematopoiesis of Iron Overload Bone Marrow "

The research-group hypothesized that iron overload could increase the ROS of BM, and then result in the deficient hematopoiesis.

They found out that the ROS in the hematopoietic cells of Bone Marrow "from 26 patients with iron overload (16 cases with myelodysplastic syndromes and 10 cases with myelofibrosis) was much higher than that of normal control
in accord with the lower production of hematopoietic colony forming (CFU-E, BFU-E, CFU-GM and CFU-mix) in patients with iron overload."

After 6-months of iron chelation therapy with deferasirox/Exjade the ROS decreased distinctly and the the hematopoietic colony forming recovered.

"As a result, 20 cases (76.9%) reduced blood transfusion, 12 cases (46.2%) increased neutrophil counting, 7 cases (26.9%) increased platelet counting, and 4 cases (15.4%) reduced the cytopenia."