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  #1  
Old Sun Nov 9, 2014, 06:52 PM
robsp robsp is offline
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Location: Sao Paulo,Brazil
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Where Do I find normal values of bone marrow aspirate and immunophenotyping ?

Im from Brazil, 42 yo and one year ago I discovered male breast cancer. Its rare cancer in man and started full treatment of cancer: surgery, chemo, radiation and anti-hormone treatment for people that know breast cancer I am using tamoxifen.

Unfortunately, now, 6 months of my chemo, 4 months after radiation and 4 months of tamoxifen my WBC is around 2.1 (normal is above 3.7), my neutrophil count is 0.9 , normal is above 1.7. My Red blood count is recovering well and is now almost normal and platelets is 140.

Last week I made a bone marrow biopsy, but I still have to wait one more week until I return to visit the oncologist.

The conclusion of aspirate reports was hyperplasia of megakaryocytes, discrete dysplasia of megakaryocytes and discrete bone marrow hypocellularity. The conclusion of other reports (Bone Marrow Biopsy,immunophenotyping and karyotype), are normal if I understood correctly.

I would like to better understand my bone marrow report result, but reports shows no reference or normal values of bone marrow aspirate and immunophenotyping.

Im trying to google for this information,

Wintrobe's Clinical Hematology book
Bone Marrow Reference Ranges
http://books.google.com.br/books?id=NYCeAgAAQBAJ
Page 13

http://www.healthsystem.virginia.edu...nceranges.html

http://path.upmc.edu/cases/case693.html

but I do not know if I can trust these sources.

I am also looking for more information what is normal result of immunophenotyping of the following antigens: CD20, CD3, Glycophorin, Factor VIII, CD34, CD117 and AE1/AE3.

Do Anyone knows where I can find normal ranges of bone marrow reports ?
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Old Mon Nov 10, 2014, 01:37 PM
Neil Cuadra Neil Cuadra is offline
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I'm not familiar with the Wintrobe book, but you can trust the information at the university websites. Keep in mind that different sources use different reference ranges, and that's true for peripheral blood counts too, but they are all close enough to let you identify what's normal and what's clearly out of range.

I suggest asking your oncologist to explain the bone marrow biopsy results to you. If you are outside the normal range for some of these antigens and other measures, ask if it matters. A doctor who is familiar with your history and your current condition is in the best position to tell you what measures are important and what they mean for your treatment.
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Old Tue Nov 25, 2014, 09:23 PM
robsp robsp is offline
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Thak you for your reply Neil. Although my exams are not completely normal my MO said that it is not possible to diagnose some kind of myelodysplastic syndrome or other kind of bone marrow failure. The MO decided to do nothing now and just continue to measure the blood counts. My last blood count shows some improvement , my WBC is now 3.1 and neutrophil count is 1.6.
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