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Sat Dec 11, 2010, 05:21 PM
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ASH 2010 Iron Overload Accelerates Development of Leukaemia - Mouse Model
http://ash.confex.com/ash/2010/webpr...aper30623.html
122 Iron Overload Accelerates Development of Leukaemia: Evidence From a Mouse Model Transfusion related iron overload is common in MDS and causes many problems. Citation: "Clinical data have suggested iron also causes haematopoietic toxicity in MDS since iron chelation can lead to dramatic reduction in transfusion requirements and in large registry studies leukaemia-free survival is inversely related to serum ferritin." These observations had previously not been supported by data. In a mouse model this study leads to the conclusion that" iron is mutagenic in haematopoietic cells and can promote progression of a pre-leukaemic state to frank AML."
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Margarete, 54, living in Vienna, Austria, MDS/AML M2, diagnosed 9/2007, then Chemos, aSZT 4/2008, chronic GVHD Last edited by akita : Sat Dec 11, 2010 at 05:45 PM. 
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