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  #1  
Old Sat Dec 14, 2013, 12:07 AM
Heather8773 Heather8773 is offline
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How long after BMT?

How long after BMT until y'all had normal counts? My husband is on day +65
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Heather, wife of Ronald 36; dx PNH 2012; Dx VSAA 2013; eculizumab(Solaris) hATG 2/20/13 cyclosporine 400 mg daily. 37 units RBC and 15 units of platelets. Post BMT -pentam,vorconizole,valtrex, valcyte, actigall, Pepcid , prograf, magnesium.
10/10 MUD 10/10/13
Now no PNH or AA. Mixed Chimerisim
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  #2  
Old Sat Dec 14, 2013, 11:02 AM
Whizbang Whizbang is offline
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I'm D+44, and all my counts have been in the normal range except for RBC's(3.56) and HGB(10.5)...

Different people see different counts come in first, and some lag behind depending on different factors...

Some I've come across at D+(near 100) still didn't have normal WBC's, some had low HGB/RBC....

One guy was at D+70, and still had HGB of 6.8 - 7.0...

Misread the post...
I started to see .1 WBC on D+10, but D+14 is typical... and they start cascading from there...
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Married, father of three daughters; now 46; diagnosed w/ Major form MDS 6/18/2013; had low counts across the board; Multiple chromosome abnormalities; Finished 2nd round Dacogen 9/13; SCT - Oct. 31, 2013; Sibling match 10/10 ; 5.5% blasts down to 3%, now 1% (post BMT)
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  #3  
Old Sun Dec 15, 2013, 09:30 PM
dfantle dfantle is offline
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Quote:
Originally Posted by Heather8773 View Post
How long after BMT until y'all had normal counts? My husband is on day +65
Hi Heather, as Whizbang mentioned achieving normal counts is different for everyone. For me, normal counts in all 3 cell lines took about 5 months. One thing that can keep the counts from normalizing is the immunosuppression medication.

-My white cells & neutrophils hit the normal range around day 21 which was also the first day my labs showed these engrafted. (Neutrophils were still just .24 (240) on day 17. Typically white cells will be the first cell line to engraft)
-My platelets were well into the normal range by day 16 & my last platelet transfusion was around day 3. (Oddly the platelets were the first cell line to normalize when they soared to 300. This had all the experts shaking their heads.)
-My red cells normalized at about 5 months. (My last red cell transfusion was 3-1/2 months post transplant, HB normalized at 5 months & although my HCT was 1 pt shy of normal until about month 7, it was so close to normal I considered it to be normal)

When I lowered my cyclosporine dose to 100mg 2x day in late November (10 months) my HCT bumped to 40

Best,
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Dena
Age 54; DX Heavy Chain (AH) Amyloidosis 6/10; AutoSCT 3/11; Amyloidosis remission 6/11; DX SAA 7/11; Horse ATG 3/12; Mini MUD SCT 1/13; Recovered from SAA 5/13 & feeling great
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  #4  
Old Sun Dec 15, 2013, 10:14 PM
Tii Tii is offline
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New normal

I had my BMT 12/2012, was transfusion dependent until 8/2013, platelets still only 65 at 12/2013. Dr said I might never be back to normal, but this is the new normal and I can function just fine!

Tii - 37 MDS/T-cell leukemia, BMT 12/2012, sister donor.
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  #5  
Old Mon Dec 16, 2013, 09:37 AM
Whizbang Whizbang is offline
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As Dena points out (dfantle), the medications you are on have a huge effect on certain blood components... The fewer medications you're on the faster certain blood components will recover...

While at Hope lodge I had quite a few discussions with BMT patients about this... As many patients react differently to certain drugs, and some medications can repress certain blood components in a bad way...
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Married, father of three daughters; now 46; diagnosed w/ Major form MDS 6/18/2013; had low counts across the board; Multiple chromosome abnormalities; Finished 2nd round Dacogen 9/13; SCT - Oct. 31, 2013; Sibling match 10/10 ; 5.5% blasts down to 3%, now 1% (post BMT)
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  #6  
Old Tue Dec 17, 2013, 11:32 PM
Heather8773 Heather8773 is offline
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Thx y'all is it normal to go up and down in counts? My husbands WBCs seem to keep going back to 1.? And then he gets neupagen. His plts dipped back 15 pts
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Heather, wife of Ronald 36; dx PNH 2012; Dx VSAA 2013; eculizumab(Solaris) hATG 2/20/13 cyclosporine 400 mg daily. 37 units RBC and 15 units of platelets. Post BMT -pentam,vorconizole,valtrex, valcyte, actigall, Pepcid , prograf, magnesium.
10/10 MUD 10/10/13
Now no PNH or AA. Mixed Chimerisim
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  #7  
Old Wed Dec 18, 2013, 03:22 PM
dfantle dfantle is offline
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Quote:
Originally Posted by Heather8773 View Post
Thx y'all is it normal to go up and down in counts? My husbands WBCs seem to keep going back to 1.? And then he gets neupagen. His plts dipped back 15 pts
Hi Heather, my team told me it can take a year for counts to normalize.

Neupogen shots can redirect the energy from making platelet and/or red cells, to making white cells. It's a delicate balance and there are different theories on giving neopogen shots post transplant, depending on length of time post transplant, levels of neutrophils... I definitely experienced this relationship when I regularly required transfusions and neupogen prior to my transplant.

A few questions:

Is he still under the care of his transplant team?
How long post transplant did he begin receiving neupogen?
How low are they letting his neutrophils go before they give him neupogen?
How high have all his counts risen since his transplant?

Best,
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Dena
Age 54; DX Heavy Chain (AH) Amyloidosis 6/10; AutoSCT 3/11; Amyloidosis remission 6/11; DX SAA 7/11; Horse ATG 3/12; Mini MUD SCT 1/13; Recovered from SAA 5/13 & feeling great
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  #8  
Old Wed Dec 18, 2013, 04:46 PM
mausmish mausmish is offline
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Heather, I recall reading somewhere (sorry I can't find the source) that it is common for counts to go down around day +60...something about the new cells' first "turnover". Sorry I don't have more info but I vaguely remember talking about it with the nurse or doctor after my bmt. Karen
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #9  
Old Wed Dec 18, 2013, 05:42 PM
vickij vickij is offline
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Heather

I had my transplant in June. I did good the 1st few months, my main problem was weakness & pain in my arms & legs. At about 3 mo. my hemog. started to drop to about 6. Every few weeks I would have to get transfusion of 2 units. This past week it dropped to 5.4 & I had to have 3 units.
The Drs are not sure what is causing it. They said everyone reacts different.
They are cutting back on some of my meds to see if that helps.
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62 yr old female. dx AA 3/12.treated with ATG 4/12.dx MDS 4/13. MUD BMT on June 25th,2013
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  #10  
Old Thu Dec 19, 2013, 12:29 AM
Heather8773 Heather8773 is offline
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Thank y'all so much for your replies! They are all insiteful!
Yes as of two weeks ago he started to go once a week bc he's been doing pretty good.
He has had 6 shots. 2 while in the hospital around day 15..4 since being released 10/30/13
Even when he was at 1.9 on his WBCs last week his nutriphils were in the upper end of normal. I'll have to ask to see why they give it sometimes and why not.
Well his WBCs have got to almost 6 but I don't trust that bc it was after neupagen. They keep trickling back down.
His HGB seems to be standing still the last couple weeks at 12.8
His plts went from 169 to 150 (earlier I said 15 pts but I guess it's really 19 pts back)
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Heather, wife of Ronald 36; dx PNH 2012; Dx VSAA 2013; eculizumab(Solaris) hATG 2/20/13 cyclosporine 400 mg daily. 37 units RBC and 15 units of platelets. Post BMT -pentam,vorconizole,valtrex, valcyte, actigall, Pepcid , prograf, magnesium.
10/10 MUD 10/10/13
Now no PNH or AA. Mixed Chimerisim
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  #11  
Old Thu Dec 19, 2013, 11:00 PM
Heather8773 Heather8773 is offline
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We got a call his cimerisiums have gone down
It was 100% donor in one that now 95% donor 5% him
The other was 92% donor 8% him now it's 70% donor 20% him
Has anyone experienced this!!!!!
So ready for this nightmare to become a dream
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Heather, wife of Ronald 36; dx PNH 2012; Dx VSAA 2013; eculizumab(Solaris) hATG 2/20/13 cyclosporine 400 mg daily. 37 units RBC and 15 units of platelets. Post BMT -pentam,vorconizole,valtrex, valcyte, actigall, Pepcid , prograf, magnesium.
10/10 MUD 10/10/13
Now no PNH or AA. Mixed Chimerisim
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  #12  
Old Fri Dec 20, 2013, 08:27 AM
sstewart09 sstewart09 is offline
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I'm not certain, but I think it depends on how his counts are doing. If they are trending down then doctors might give him an infusion of donor cells. If they are stable, then they'd just monitor him. I have heard of people doing just fine with a mixed chimerism. I know it's a roller coaster and it stinks that everything is out of your control. Keeping you guys in my thoughts and prayers!
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Samantha, wife of Joe age 34; diagnosed vsaa 2012; MUD BMT February 2013
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  #13  
Old Fri Dec 20, 2013, 11:05 PM
Heather8773 Heather8773 is offline
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Thank you his team said they will try lowering the prograf and if that doesn't work then they will get more cells. So scary;(
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Heather, wife of Ronald 36; dx PNH 2012; Dx VSAA 2013; eculizumab(Solaris) hATG 2/20/13 cyclosporine 400 mg daily. 37 units RBC and 15 units of platelets. Post BMT -pentam,vorconizole,valtrex, valcyte, actigall, Pepcid , prograf, magnesium.
10/10 MUD 10/10/13
Now no PNH or AA. Mixed Chimerisim
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  #14  
Old Sat Dec 21, 2013, 11:11 AM
Whizbang Whizbang is offline
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Heather,

If you noticed my thread, all my counts (except for RBC / Hemoglobin) are trending down lately... I'm lucky that they were all so high initially... My Platelets are now down to 117...

Doctor says this is normal, and is indeed due to turnover (life span of the different blood cells)... Again, it can take quite a while for blood to stabilize, and there may be some bumps in the road...

As for the lingering cells, that has alot to do with pre-BMT conditioning, and it's a trade off...

I had the most aggressive possible conditioning, so it is unlikely I kept any of my own cells... (11 TBI treatments, 2 separate Chemo + rATG)...

It's all a trade off, as aggressive conditioning can bring on more complications pre/post BMT...
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Married, father of three daughters; now 46; diagnosed w/ Major form MDS 6/18/2013; had low counts across the board; Multiple chromosome abnormalities; Finished 2nd round Dacogen 9/13; SCT - Oct. 31, 2013; Sibling match 10/10 ; 5.5% blasts down to 3%, now 1% (post BMT)
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  #15  
Old Sat Dec 21, 2013, 11:25 PM
Heather8773 Heather8773 is offline
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Thank you I did notice that on your thread. My husbands hgb seems to be about the same as well. I hope his chimerisms sort out soon.
Good to know that your Drs confirmed the "turn over" also bc his dipped around the time frame y'all are saying . Close to day 60
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Heather, wife of Ronald 36; dx PNH 2012; Dx VSAA 2013; eculizumab(Solaris) hATG 2/20/13 cyclosporine 400 mg daily. 37 units RBC and 15 units of platelets. Post BMT -pentam,vorconizole,valtrex, valcyte, actigall, Pepcid , prograf, magnesium.
10/10 MUD 10/10/13
Now no PNH or AA. Mixed Chimerisim
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  #16  
Old Sun Dec 22, 2013, 12:56 PM
dfantle dfantle is offline
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"Even when he was at 1.9 on his WBCs last week his nutriphils were in the upper end of normal. I'll have to ask to see why they give it sometimes and why not."

Heather, IMHO I can't think of any reason why a transplant team would continue to give Ronald GCSF if his neutrophils are in the upper end of normal, especially given where his other counts are. Unless he was still dealing with severe neutropenia and suffering from regular infections I don't think an experienced team would give GCSF at the intervals you suggest post transplant without a solid reason. I would seriously question why they are doing this and ask maybe even for data to back it up.

I'm so sorry to come across so strongly here & dont want to upset you but even with my minimal experience & understanding, it just seems off. Prior to transplant, I regularly gave myself GCSF shots when my neutrophils fell below 500 (.5) for 1-1/2 years, under very close watch from my Hematologist. When I switched to the transplant team 1 month prior to my MUD transplant, my transplant Dr's at Fred Hutch in Seattle were adamant I stop my GcSF several weeks prior to transplant regardless of my counts, and very clearly told me I would not have this post transplant unless it was very clear I didn't engraft by day 30 + (I believe this may be longer for full transplants but I had a mini-so engraftment should have been between day 14-21 & I engrafted at day 21).

All my best,
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Dena
Age 54; DX Heavy Chain (AH) Amyloidosis 6/10; AutoSCT 3/11; Amyloidosis remission 6/11; DX SAA 7/11; Horse ATG 3/12; Mini MUD SCT 1/13; Recovered from SAA 5/13 & feeling great
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  #17  
Old Sun Dec 22, 2013, 06:46 PM
DebS DebS is offline
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Heather,

Doug is off Prograf altogether and has been for some time now. His kidneys were taking such a hit that the doctor didn't think he could keep him on it. He is now on Cellcept (sp?) and that dosage has been increased.

He did have GVHD of the skin and has been on steroids as well. But the doctor thinks that this combination is working well for him.

They have to adjust and adjust and then readjust the meds. It is such a delicate balance, as many have said.

Take a breath, hang in there, and KEEP asking questions. They will get it right. I am sure that your husband is getting great care and has a lot of expert opinions in there. But for your sanity, get your questions answered!

Good luck and God bless!

Deb
P.S. Oh yeah, throw Merry Christmas in as well
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  #18  
Old Mon Dec 23, 2013, 10:54 AM
DebS DebS is offline
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Heather,

When I read your comment about this being a nightmare, I wanted to tell you what I have done throughout. I sing Avicii's "Wake Me Up" at the top of my lungs!!!

Prayers and good thoughts coming your way.

Deb
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  #19  
Old Mon Dec 23, 2013, 01:50 PM
mausmish mausmish is offline
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Great song, Deb. It's on our lengthy tagline list for future blog posts. Heather - a scary time for you and your husband. Hoping it's simply the 60-day slump and sending many healing thoughts your way. Wishing you the happiest of holidays that the circumstances allow! I had my BMT 3 years ago on Nov. 30. It was a tough holiday time with chemo for Thanksgiving and post transplant recovery for Christmas and New Year's. Now, it's just a bad memory as I happily celebrate being alive with 100% donor cells. I definitely got the best gift possible!
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #20  
Old Mon Dec 23, 2013, 06:29 PM
Heather8773 Heather8773 is offline
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Dena, thank you very interesting. I will defenantly be asking. They don't mind I think they expect I'll ask at least something his nutriphils stay consistant it's just the other white cells that always go out of wack changing all kind of ways. Did you ever have a change in chimerism?
Deb I love that song!!! I blare it when I'm nervous! Especially when I would run errands while my husband was in the hospital. I'm happy to see they have got Doug on a good balance! Wishing y'all a very happy Christmas, new year and continued good news!!
Mausmish did you ever experience a change in chimerisms? Im Happy your 100% now!
His Dr said 60 days is about when the blood type changes over so they see a drop while that's happening. So they will check his blood type next time I wonder if 60 days effects the chimerism?
Happy holiday and thank y'all my husband and I are feeling more at ease from yalls responses!
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Heather, wife of Ronald 36; dx PNH 2012; Dx VSAA 2013; eculizumab(Solaris) hATG 2/20/13 cyclosporine 400 mg daily. 37 units RBC and 15 units of platelets. Post BMT -pentam,vorconizole,valtrex, valcyte, actigall, Pepcid , prograf, magnesium.
10/10 MUD 10/10/13
Now no PNH or AA. Mixed Chimerisim
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  #21  
Old Mon Dec 23, 2013, 07:13 PM
mausmish mausmish is offline
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Heather, my chimerism has not changed. I've been 100% donor since Day +30. But everyone is different, and I've read many accounts of others with mixed chimerism and no problems.
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #22  
Old Tue Dec 24, 2013, 02:10 AM
dfantle dfantle is offline
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Hi Heather, I have not seen a reduction in my chimerism, however my blood type was the same as my donors and perhaps that helped.

I have also heard of patients with mixed chimerism & no issues, especially as close to transplant as Ronald.

Best,
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Dena
Age 54; DX Heavy Chain (AH) Amyloidosis 6/10; AutoSCT 3/11; Amyloidosis remission 6/11; DX SAA 7/11; Horse ATG 3/12; Mini MUD SCT 1/13; Recovered from SAA 5/13 & feeling great
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  #23  
Old Mon Jan 6, 2014, 05:58 PM
Heather8773 Heather8773 is offline
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Thx y'all, yalls responses were helpful and comforting! His new Cimerism test said his granulocytes are back to 100% donor and the mononuclear are going up and now at 81%! Yaaaay! This was after a week of lowering prograf. I asked if this would continue to go up as the prograf level is still lowered and his DR said in the beginning it's normal to see the Cimerism wobble back and forth and then even out. He said that's fine as long as the blood counts don't start dropping (dramatically? I'm guessing)
Anyway I'm happy their going up!
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Heather, wife of Ronald 36; dx PNH 2012; Dx VSAA 2013; eculizumab(Solaris) hATG 2/20/13 cyclosporine 400 mg daily. 37 units RBC and 15 units of platelets. Post BMT -pentam,vorconizole,valtrex, valcyte, actigall, Pepcid , prograf, magnesium.
10/10 MUD 10/10/13
Now no PNH or AA. Mixed Chimerisim
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  #24  
Old Tue Jan 7, 2014, 09:22 PM
kris kris is offline
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Individuality!

Heather,
I can only remind you every patient is different. Thus the plan of care is different. Rick has been on sirolimus and tacrolimus for his immunosuppressants. He still is on decreasing tacrolimus at 2 years. All counts were not nornal until after 16 months. That being said he was never on epogen, aranesp nor neupogen post transplant. Nor did he require any transfusions.
JUST monitoring, excellent hygiene, good nutrition, following medical advise and taking all meds as prescribed. If something didn't seem normal for him, difference in his or my evaluation of him we brought it to the staffs attention. The slightest thing.
We stayed away from infants, animals and sick people. Rick wore a mask for the better part of that time especially with every Dr appointment...sick people are in clinics and hospitals. Everyone is immunosuppressed at BMT. (Who knows what bacteria or virus someone is carrying). When dietary restrictions were lifted at day 100+, OUR ATTITUDE was "Is today different than yesterday?" No!... so let's stick with what we know. Reminding ourselves his immune system was less than 100 days. We stayed on restricted diet for nearly a year until we felt comfortable adding new foods and going out. The few times we went out I had the waiter bring a cup of boiling water to soak the utensils in. Ordered food cooked to 165 degrees, never had the salad bar, nor raw onions or lemons in water.Ww wiped the table and chairs with clorax wipes. Precautions we feel to this day has made a difference. If we feel uncomfortable in a restaurant, home or event we leave. Could it be viewed obsessive...yes. Has it been worth it mentally...absolutely. Rick is at his post MDS diagnosis self....that is a lll we can ask for. he has exchanged a terminal diagnosis for management of chronic diseases which are under control.
Heather we wish you well, every journey is different. If it feels right it is, if there is something different for yu..mention it to your doctor.
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  #25  
Old Wed Jan 8, 2014, 01:03 AM
Heather8773 Heather8773 is offline
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Kris thank you your response is perfect timing! My husband is approaching 100 days and I'm a total safe then sorry person (only exception was we were around our little dogs around day 60 but w extrem caution [other then sleeping w us;/) but I have been questioning lately if I'm to strict w "the rules" bc I feel like in other peoples eyes i am and my husbands been patient but I think he's so ready for the relax in rules at 100 at this point. Your right though whats 24hrs? When things have been working. My fave advise a PCA gave us was " look. I've played and joked w y'all but now I'm going to be serious. The people that end up admitted back here or even worse don't follow the "rules" (of course she didnt mean things out of our control) they are so ready to get back to the things they did (crazy things like smoking outside at under 40 + ....etc..) but there are things happening in your body that are so complex and profound. They are just going to take a year ( at least) to heal and complete. So I don't care if your feeling good full of energy. Don't over do it, these things take time!"
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Heather, wife of Ronald 36; dx PNH 2012; Dx VSAA 2013; eculizumab(Solaris) hATG 2/20/13 cyclosporine 400 mg daily. 37 units RBC and 15 units of platelets. Post BMT -pentam,vorconizole,valtrex, valcyte, actigall, Pepcid , prograf, magnesium.
10/10 MUD 10/10/13
Now no PNH or AA. Mixed Chimerisim
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