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Old Fri Jun 7, 2019, 08:12 PM
JoMac53 JoMac53 is offline
Join Date: Sep 2017
Posts: 63
WBCs suddenly going up, including neutrophils

Does it mean anything bad when WBCs suddenly go high? I seem to recall reading somewhere that it did but can't find anything now.

Right from the start I was critically neutropenic and stayed that way for 2 years. In the past several months I've had several weeks in a row where my ANC was high enough (1.0) that I didn't need the Granix shot. But now the ANC itself has risen so much (8.5) it's over the lab's normal range (1.8-8.0). Lymphs & monos are also over the labs normal range.

Any ideas?
Joanne, 65F, Primary MDS-EB1, Pancytopenia, 8/17. Weekly CBC, Granix shot if ANC below 1.0.
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Old Sat Jun 8, 2019, 01:10 PM
JoMac53 JoMac53 is offline
Join Date: Sep 2017
Posts: 63
WBCs going up while taking Keflex

So checked back on lab reports and all those WBCs started going up at the same time I started taking Keflex for cellulitis on my shin from a bump injury. BMB on Wed and regular CBC on Friday so I guess I'll see if they've started going down or if it has nothing to do with is. This disease is so weird.

And I don't know where everyone is but it seems like there are not a lot of posts here anymore. Is everyone on Facebook? lol
Joanne, 65F, Primary MDS-EB1, Pancytopenia, 8/17. Weekly CBC, Granix shot if ANC below 1.0.
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Old Mon Jun 10, 2019, 02:22 AM
Hopeful Hopeful is offline
Join Date: Jan 2009
Location: California, USA
Posts: 715
Hi JoMac3,

I'm glad that there is a good reason for the rise in WBC I hope Keflex knocks out the infection!
52 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. Tried slow cyclosporine taper over 4+ years. Platelets fell, so back on cyclosporine. Trisomy 6 clone in 5% of cells.
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Old Mon Jun 10, 2019, 04:07 AM
DanL DanL is offline
Join Date: Dec 2010
Location: Denver, CO
Posts: 566
higher wbc can also mean that you are fighting a bacterial infection, and also rise from taking prednisone. it usually indicates that your system is responding the way that it should, so long as you are not getting too much above about 12,000 total, at which point if you are not taking steroids, there may be some concern.

i am glad this just seems to be related to your keflex usage.
MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD.
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Old Wed Jun 12, 2019, 01:44 AM
Cheryl C Cheryl C is offline
Join Date: Dec 2011
Location: Lake Macquarie, Australia
Posts: 829
Hi JoMac53

My WCC always rises during an infection. It drops soon after completing antibiotics.

I've had a sudden drop in platelets from 130 down to 84 in the last couple of months and I'm hoping it's due to the virus (bronchitis, sinusitis) I had in April which took 5 weeks to get over.

Any thoughts?
Dx MDS RAEB 10% blasts + hypogammaglobulinemia, Sep 2011. Jan 2012 BMB - blasts down to 2% w/out treatment so BMT cancelled. Re-diagnosis RCMD. On watch and wait since Feb 2012. IVIg 5-weekly. BMB Feb 2014 - no blast transformation. 2018 still stable.
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Old Fri Jun 14, 2019, 03:38 PM
maggiemag maggiemag is offline
Join Date: Sep 2012
Location: Cincinnati, OH - United States
Posts: 85
Hi Jo. The good news is that it went up in response to an infection!! That means you can make some white cells. Cellulitis is no joke, and can be quite serious. Also, even if not on a steroid like Prednisone routinely, your WBC can go up briefly and temporarily after steroid injections. I've noticed that after shots in various joints from the rheumy. It would be normal ANC afterwards and then go back down the following week to my normal!
Margaret, age 68, dx MDS 5 q- 5/09- now RCMD; also MGUS
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