Home         Forums  

Go Back   Marrowforums > Treatments > Transfusions and Iron Overload
Register FAQ Search Today's Posts Mark Forums Read

Transfusions and Iron Overload Blood and platelet transfusions, iron testing and treatments

Reply
 
Thread Tools Search this Thread
  #1  
Old Sun Dec 1, 2013, 03:30 PM
gramous gramous is offline
Member
 
Join Date: Apr 2012
Location: belgium
Posts: 73
iron overload without transfusion

Hallo every one,

my boyfriend has mds rars-t without cytogenics change and he's NO transfusion dependant. But he has too much ferritine. Has anyone that and what is your level? His is 900 µg/l. Any advise is welcome :-) thank you
__________________
boyfriend with RARS-T dx 11/02//dx : hb 11,5; plt 870000, wh : 6500//Before fasting cure (13/04): hb: 8,9; plt 2200000; white:6000//After fasting cure (14/09): hb 12,5; platelets 400000, wh 3000.//Now (15/08) : hb : 11,plt : 650000, wh 3000// hydrea 1c/day and cardioaspirin, 1c/day,age: 56 y.
Reply With Quote
  #2  
Old Mon Dec 2, 2013, 06:02 AM
Mseth Mseth is offline
Member
 
Join Date: Sep 2013
Location: New Delhi, India
Posts: 186
My mother's ferritin at dx was 983, this was before any transfusion. She has RCMD with ringed sideroblast.
I read that many MDS patients have high ferritin at diagnosis and before transfusion.
Ferritin is also a marker of inflammation, it may come down on its own if it is due to that.
Or maybe since RBC production is low, the iron is not used and stays in the blood or converts to ferritin. I may be completely wrong on this one.
__________________
Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
Reply With Quote
  #3  
Old Mon Dec 2, 2013, 07:45 AM
Birgitta-A Birgitta-A is offline
Member
 
Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Ferritin

Hi béné and Mseth,
Many MDS patients have hemolysis (the red blood cells burst too early) and that will lead to a high ferritin level. You know normal red blood cells will live about 120 Days.
Kind regards
Birgitta-A
Reply With Quote
  #4  
Old Mon Dec 2, 2013, 08:53 AM
Mseth Mseth is offline
Member
 
Join Date: Sep 2013
Location: New Delhi, India
Posts: 186
Hemolysis

Hi Birgitta-A,

Some years back, before the MDS dx, my mother had several tests for hemolytic anemia, i am not sure what those tests were but she tested negative for that. Can hemolysis of blood cells happen even then?

I still do not understand if her marrow produces too less RBC, or if they are not formed properly or they break prematurely.

Thanks for always helping us understand MDS.
__________________
Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
Reply With Quote
  #5  
Old Tue Dec 3, 2013, 05:02 AM
Birgitta-A Birgitta-A is offline
Member
 
Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
MDS

Hi Mseth,
I think we can have hemolysis without the special tests being positive - I have that myself. Often our bone marrow can not produce enough red blood cells, then they are dysplastic (not properly shaped) and breake too early.
Kind regards
Birgitta-A
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
ASH Japanese Study on Iron Overload mesuring after allogeneic HSCT akita Transfusions and Iron Overload 0 Thu Dec 16, 2010 01:20 PM
ASH 2010 Highly Transfused MDS Patients Often Have Cardiac Iron Overload akita Transfusions and Iron Overload 0 Wed Dec 15, 2010 05:21 PM
ASH 2010 Iron Overload results in deficient Hematopoiesis akita Transfusions and Iron Overload 0 Sat Dec 11, 2010 04:43 PM
ASH 2010 Iron Overload Accelerates Development of Leukaemia - Mouse Model akita Transfusions and Iron Overload 0 Sat Dec 11, 2010 04:21 PM
Iron Overload, Liver and Heart Function Francine S Transfusions and Iron Overload 7 Mon Jun 1, 2009 01:01 PM


All times are GMT -4. The time now is 05:41 AM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2019, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright © 2006-2019 Marrowforums.org