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Bone Marrow Failure Causes, treatment approaches, terminology, related diseases

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Old Mon Oct 30, 2017, 06:11 AM
Danielle S Danielle S is offline
Join Date: Oct 2017
Location: MI
Posts: 1
Decipher Bone Marrow Results

I am hoping someone can help decipher the meaning of these bone marrow results.

Mildly hypercellular marrow with trilineage hematopoiesis and lymphoid aggregates. The biopsy shows scattered small, aggregates of mature lymphocytes, which is unusual at this age. No abnormal spindled mast cells are evident, and by immunohistochemistry, mast cell tryptase highlights rare scattered mast cells. Reticulin stain shows increased fibrosis (MF-2). CD3 and CD20 highlight a mixture of T and B cells within the lymphoid aggregates.
CD10 is essentially negative on the lynphocytes. Immunohistochemistry controls are examined and show appropriate reactivity

PERIPHERAL BLOOD SMEAR INTERPRETATION: Mild normocytic normochromic anemia.

Oncology BLD BM Chromosome Analysis
INTERPRETATION All but one cell analyzed contained a 46XX normal female karyotype. The remaining one cell contained 45 chromosomes with loss of one copy of chromosome 7 which was a non-clonal chromosome change
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Old Wed Nov 29, 2017, 12:19 PM
barbarth barbarth is offline
Join Date: Nov 2017
Location: Ithaca, New York
Posts: 1
understanding bone marrow biopsy

I too am trying to understand terms in my bone marrow biopsy. Now that I'm typing an answer, I can't see your message, which is unhelpful. I'm far from expert, but I believe your biopsy says you're at stage two of myelofibrosis (out of four stages, I think). I'm sorry if I'm alarming your unneccessarily and hope you get good medical care from a specialist. There were a couple of other things I recognized from your excerpt, but can't see it and can't recall.
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Old Wed Nov 29, 2017, 05:05 PM
Marrowforums Marrowforums is offline
Join Date: Jul 2006
Posts: 878
Originally Posted by barbarth View Post
Now that I'm typing an answer, I can't see your message, which is unhelpful.
Forum tips:
While you are composing your message, scroll down the page. You'll see Danielle S's message at the bottom of the page.

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