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  #1  
Old Sat May 21, 2011, 12:17 PM
Birgitta-A Birgitta-A is offline
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Thumbs up No AML from Neupogen or similar drugs

Hi All,
Here is a report about patients treated with Neupogen or similar drugs. The patients had no increased risk for AML transformation and a better overall survival. The results are in agreement with recent reports, confirming that GCSF treatment does not increase the risk of AML transformation.
http://www.abstractserver.com/mds201...k7nston62kni20

Kind regards
Birgitta-A
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  #2  
Old Tue May 24, 2011, 10:02 PM
cheri cheri is offline
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Neupogen vs Neulasta

Is there any indication/evidence that the results would be similar with Neulasta? My Dr seems to think that Neupogen is the safer alternative, and has heard some negative things about the longer lasting Neulasta...
Any more info out there we can look at--currently I take Neupogen 5 days post Vidaza...thanks!
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Cheri Age 54; dx Oct 2009 AML, induction chemo only;dx MDS July 2010,- PRBC transfusion dependent; Results BMB 8/4/11--- 6-8% blasts; Danazol 100 mg 3xday; quit Exjade/ GI distress; platelets holding 40's; Fluctuation in blasts in blood--Neupogen 3-4xweek; off Revlimid again! Procrit weekly
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Old Wed May 25, 2011, 04:45 AM
Birgitta-A Birgitta-A is offline
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Neupogen vs Neulasta

Hi Cheri,
As far as I remember I have not read anything about Neulasta but they never mention in the acstracts what type of granulocyte colony stimulating factor they use. We don't know if it is Neupogen, Neulasta or some other brand.
Kind regards
Birgitta-A
Neupogen 2 injections/week since neutropenic fever Sept 2007
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  #4  
Old Wed May 25, 2011, 09:54 AM
cheri cheri is offline
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Neupogen vs Neulasta

Hi Birgitta~
Well, the fact that you have been on regular Neupogen for 4 years speaks for itself.....
I wonder where we might find more information on Neulasta, and how it differs from several doses of Neupogen. My Dr says it's "long term" stimulator, but what does that mean, exactly...
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Cheri Age 54; dx Oct 2009 AML, induction chemo only;dx MDS July 2010,- PRBC transfusion dependent; Results BMB 8/4/11--- 6-8% blasts; Danazol 100 mg 3xday; quit Exjade/ GI distress; platelets holding 40's; Fluctuation in blasts in blood--Neupogen 3-4xweek; off Revlimid again! Procrit weekly
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  #5  
Old Wed May 25, 2011, 03:20 PM
Birgitta-A Birgitta-A is offline
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Neupogen vs Neulasta

Hi cheri,
Amgen makes both drugs. Neulasta is a modern drug and stays longer in the body because it has a large chemical called polyethylene glycol (or PEG) added to one end of the Neupogen molecule. At the same time Neulasta is difficult to monitor - if you for example get pain from the joints the adverse effect will last much longer.
http://www.neulasta.com/patient/howc..._neupogen.html

When I have tried different drugs for iron overload like Ferriprox (not approved in the US) and a normal dose of Exjade I have been taking Neupogen every day to increase the very low WBCs. The same thing happened when I started to take Thalidomide 50 mg/day - I can only take 50 mg 4 times/week.
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Birgitta-A
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