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MDS Myelodysplastic syndromes

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Old Sat May 30, 2015, 07:52 AM
Data Data is offline
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Question MDS and ALL or CLL???

I have the preliminary results of my latest bone marrow biopsy and am concerned. One part of the report states:
T Cell Receptor (TCR) gamma chain monoclonality: Positive

Interpretation:
Monoclonal TCR gamma chain gene rearrangement is identified, which indicates the existence of a monoclonal T-cell population in this specimen. No evidence of TCR beta chain gene rearrangement is identified.

Comments:
Monoclonal T-cell population is indicative of malignancy with a few exceptions, e.g. benign clonal T-lymphocytosis and lymphomatoid papulosis etc. Clinical

My understanding is the T-cells are derived from the lymphoid blood line which would mean this is probably either acute or chronic lymphoid leukemia (ALL or CLL).

Another portion of the report states:

Deletion of 7q or monosomy 7 is detected in 20.5% of cells

Interpretation:
Del(7q)/-7 is one of the most common chromosomal aberrations in myeloid malignancies, such as de novo or therapy-related MDS and AML.

My concern is do I have cancer in both the lymphoid and myeloid blood lines?

If anyone has any thoughts I would love to hear them.

Thanks

Data
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Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
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