Home         Forums  

Go Back   Marrowforums > Bone Marrow Failure Diseases > Bone Marrow Failure
Register FAQ Search Today's Posts Mark Forums Read

Bone Marrow Failure Causes, treatment approaches, terminology, related diseases

Thread Tools Search this Thread
Old Wed Feb 25, 2015, 11:53 AM
curlygirl curlygirl is offline
Join Date: Jun 2013
Posts: 151
Role of Vitamin A in the production of human embryonic blood cells


There are two interesting thing about this article, intellectually about too much vitamin A causing low blood cell development, but more interesting for our group WHY the authors are doing the research.

Here is the why:
"Niels-Bjarne Woods' research is about finding ways of artificially generating blood stem cells for use in blood stem cell transplants to patients with blood disorders and cancers, who do not have access to a suitable donor.

"The current research findings increase our understanding of the complexity of the process of blood formation during embryonic development. We hope that this, together with new future discoveries, will lead to the generation of blood stem cells in the laboratory, which in turn can be used to treat blood disorders and malignancies," says Niels-Bjarne Woods."

Here is the Vitamin A part in summary:
"The researchers observed that increased levels of retinoic acid drastically reduced the number of blood cells that could be produced. A reduction in the retinoic acid instead increased the production of blood cells by 300 per cent. On the basis of these results, Niels-Bjarne Woods and his colleagues propose a new explanatory model of how retinoic acid affects the embryonic development of blood.

Even if vitamin A is required for a normal pregnancy, it has long been known that too much vitamin A can be damaging to the fetus, with the risk of fetal malformation and miscarriage. Pregnant women have therefore been recommended to limit their consumption of foods that are high in vitamin A in the form of retinoids, such as liver."
Reply With Quote
Old Thu Feb 26, 2015, 02:28 AM
Chirley Chirley is offline
Join Date: Oct 2007
Location: Logan City Australia
Posts: 1,100
The anomaly is that my Vitamin A level used to be 0.2 (1.6-2.3) and I've been on replacement therapy. My latest blood test shows 1.4 and my pancytopenia has worsened. Shrug shoulders.
Reply With Quote

Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

All times are GMT -4. The time now is 08:27 AM.

Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2021, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright 2006-2020 Marrowforums.org