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Old Mon Apr 26, 2010, 03:55 PM
rnmommy9 rnmommy9 is offline
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Exjade

Hi, my mom (MDS/leukemia) had a bone marrow transplant 8 years ago. Two years ago, her leukemia came back, but an infusion of cells from her original donor put her back in remission. She was put on exjade in March, and started experiencing a large amount (as many as 10 a day) of bowel movements, many of which were diarrhea. A routine blood test last week showed her platelets were down to 76,000. Are these side effects anyone has experienced with exjade?
Thank you,
Michelle
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Old Mon Apr 26, 2010, 08:42 PM
Neil Cuadra Neil Cuadra is offline
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Michelle,

I'm glad to hear that your mom reached remission.

There is a detailed description of Exjade (deferasirox) at rxlist.com and it's not hard for us laypersons to read. You didn't mention your mom's age but MDS patients age 65 or older have adverse reactions to Exjade more frequently than younger patients.

Mild to moderate diarrhea is one of the more commonly reported side effects of Exjade. The manufacturer (Novartis) reminds patients to drink fluids. But this may be more than "moderate". I think that you or your mom should talk to the doctor about it soon, if you haven't already, in case the dosage ought to be changed. If she needs treatment for iron overload there may be a tradeoff of risks.

I haven't read about Exjade affecting platelets (there were some comments about it in our External symptoms from MDS? thread, but very low platelets are a possible contraindication for Exjade. Whatever the cause of the platelet drop, if they get much lower your mom may not be able to continue taking Exjade. She made need another CBC test to establish what the trend is.
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