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Clinical Trials Considering or participating in research studies

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  #1  
Old Fri Feb 1, 2013, 07:04 AM
Birgitta-A Birgitta-A is offline
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New drug for anemia in the pipeline

Hi All,
A new drug for anemia is now tested in a Phase II trial:
http://www.checkorphan.org/grid/news...stic-syndromes
Kind regards
Birgitta-A
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  #2  
Old Fri Feb 1, 2013, 11:49 AM
Neil Cuadra Neil Cuadra is offline
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The Acceleron press release has these quotes from the investigators:
The anemia experienced by patients with MDS is clinically challenging because it is often unresponsive to administration of erythropoietin and many patients ultimately require red blood cell transfusions.

ACE-536 has the potential to make a significant impact on the treatment of anemia in MDS. Unlike erythropoietin, ACE-536 may target the specific defect in the erythropoietic maturation process in MDS patients and we are optimistic that it could become an important new therapeutic option for this underserved patient population.
An additional bit of information from the Acceleron product page:
In preclinical studies, ACE-536 promoted RBC formation in the absence of erythropoietin (EPO) signaling, had distinct effects from EPO on RBC differentiation, and acted on a different population of progenitor blood cells than EPO during RBC development.
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Old Fri Feb 1, 2013, 02:46 PM
riccd2001 riccd2001 is offline
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Thanks Birgitta and Neil for the links. There's still more to do but these are very encouraging words in the PR...

"In a phase 1 clinical study of healthy volunteers, ACE-536 produced a dose-dependent increase in red blood cells and hemoglobin levels. "
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Ric: Low-risk MDS (blasts <4%); 4 cycles Revlimid no positive response; PRBC transfusion dependent; so far, 392'units' over 8 3/4 years; BMB #4 (15/04/01) shows evolution to AML (blasts 20-30%) 47,XY,del(5) (q22q35),+21[24][cp24]/46,XY(1).
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Old Wed Apr 17, 2013, 06:46 PM
riccd2001 riccd2001 is offline
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Progress takes time... latest press release

Very good to see progress with FDA classification for ACE-536 !!

http://www.acceleronpharma.com/2013/...s-for-ace-536/
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Ric: Low-risk MDS (blasts <4%); 4 cycles Revlimid no positive response; PRBC transfusion dependent; so far, 392'units' over 8 3/4 years; BMB #4 (15/04/01) shows evolution to AML (blasts 20-30%) 47,XY,del(5) (q22q35),+21[24][cp24]/46,XY(1).
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