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Drugs and Drug Treatments ATG, Cyclosporine, Revlimid, Vidaza, Dacogen, ...

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  #1  
Old Fri Apr 15, 2011, 11:52 PM
Neel Neel is offline
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Join Date: Dec 2010
Location: delhi india
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treatment option for MDS

Hi ppl,

Wanted to know what are the oral treatment option for MDS RAEB-II and their effectiveness. I mean treatment options apart from vidaza and dacogen.

Regards

Neel
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Father age 64 diagnosed with MDS RAEB-2, with 15%-18% blasts in October 2010. Only had blood and platelet transfusions. Ayurvedic treatment which showed result for arnd 5 months. Started Tahlidomide 100 mg started on 22 nd April 2011. Revolade 50 mg started on 2 nd april 2012.
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Old Sun Apr 17, 2011, 01:41 PM
Birgitta-A Birgitta-A is offline
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Location: Stockholm, Sweden
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Oral treatment

Hi Neel,
You know there are not many oral drugs for MDS – in India they don’t have so many clinical trials for MDS (like in Sweden where I live).

Your father could try Thalidomide or Revlimid – both should be combined with Prednisone the first 3 months for better response. Both these studies include low risk patients.

Thalidomide http://www.mdsbeacon.com/news/2009/0...-mds-eha-2009/
Thalidomide can give nerve damage but not so often if you only take 50 mg/day.

Revlimid http://bloodjournal.hematologylibrar..._than_deletion
Revlimid can decrease white blood cells and platelets initially. Then they now control if Revlimid can increase the risk for other types of cancer.
Kind regards
Birgitta-A
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Old Mon Apr 18, 2011, 12:57 AM
Neel Neel is offline
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Join Date: Dec 2010
Location: delhi india
Posts: 73
Thanx brig.

Thanx brig,

I was hoping to find more drugs with better response besides, revlimid and thalidomide. My father is High Risk, RAEB-II, with normal cytogenics, low platelet count and WBC count, therefore revlimid is not the option for us. Thalidomide, is an option, but doctors here are not that optimistic abt the drug. In fact doctors here are not very optimistic abt any drug, let it be vidaza or dacogen. Yes u r right there r no trials in India, and what i personally feel is that doctors here dont have much of an exposure in regard to MDS here. We tried ayurvedic treatment cos allopathic drugs had their limitations and side effects and it was a game of permutations and combinations. The ayurvedic treatment gave him 5-6 months of good results, with no side effects. We hoped that the treatment would not only treat him but cure him. But our bad luck came in the way. However we are stil hopefull that the drug might start giving its effect again soon.

With warm regards,

Neel
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Father age 64 diagnosed with MDS RAEB-2, with 15%-18% blasts in October 2010. Only had blood and platelet transfusions. Ayurvedic treatment which showed result for arnd 5 months. Started Tahlidomide 100 mg started on 22 nd April 2011. Revolade 50 mg started on 2 nd april 2012.
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