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#1
Fri Nov 13, 2009, 11:12 AM
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Article on Exjade & MDS
This was posted on the MDS patient forum. I thought it would be good to have it here also.
http://www.medscape.com/viewarticle/703030
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K. Last edited by Marlene : Fri Nov 13, 2009 at 11:43 AM. 
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#2
Fri Nov 13, 2009, 12:15 PM
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Marlene,
Only registered Medscape members can go to that URL. Is the article on PubMed too? What's the title?
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#3
Fri Nov 13, 2009, 01:04 PM
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Oh, I didn't realize that. I must be registered somehow. Let me check it out and get back to you.
__________________
Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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#4
Fri Nov 13, 2009, 02:29 PM
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It's an article written by medscape journalist and they reference abstracts/studies done by others. So there's not a pubmed equal. There's no cost to register at this site for those who want to read it.
Other than doing a cut/paste, I'm not sure what else to do.
__________________
Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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#5
Sat Nov 14, 2009, 07:52 AM
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Iron chelation and red blood cells
Hi Marlene,
There has been much discussion about iron chelation in MDS. As far as I understand the reseachers that think that chelation is important know more about the effect on immature red blood cells: http://ash.confex.com/ash/2009/webpr...aper23215.html I tried Exjade 1000 mg/day and the drug prolonged my transfusion interval from 3 to 6 weeks but my white blood cells decreased so I had to stop the medication  .Kind regards Birgitta-A
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#6
Mon Nov 16, 2009, 10:46 AM
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Hi Birgitta-A,
Sorry to hear about the drop in white cells. That's a pretty dramatic jump in red cells though. When John was on Exjade, he noticed a very small increase in red cells but nothing real notable. His doc did not think much about the effect or Exjade's potential at the time. But this was 3 years ago when no one was looking at it. Sounds like Exjade could have two applications....one to chelate and another to boost red cells. It would be good to see a study to find out the lowest possible dose of Exjade that will boost red cells. I believe the first article is really addressing that iron-overload becomes the focus versus the MDS; and to prescribe Exjade based on just FE levels and not take into consideration the type of MDS, is not a "best practice". There are many things to take into consideration when deciding a treatment path. BTW...thanks again for posting those abstracts this year Marlene
__________________
Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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#7
Mon Nov 16, 2009, 02:48 PM
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Exjade in combination with Desferal
Hi Marlene,
I think you are right about a low dose of Exjade for the red cells  ! I read about a member that had a combination of Exjade and Desferal (I am treated with Desferal again) but we have not heard the result yet. Then there are 2 clinical trials with a combination but no results yet.Kind regards Birgitta-A
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