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  #1  
Old Mon Nov 8, 2010, 02:28 PM
Marlene Marlene is offline
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Making blood

Interesting article on making blood from skin cells.

http://www.sciencedaily.com/releases...1107202144.htm
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of January 2017, FE is 233, HGB 11.7, WBC 5.1/ANC 4.0, Plts 146K.
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  #2  
Old Tue Nov 9, 2010, 01:48 PM
squirrellypoo squirrellypoo is offline
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Wow that's really cool! Thanks for posting. Having blood made from your own cells would cut down on the antibody and rejection issues that those of us who've had lots of transfusions face.
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36/F - 1984 SAA treated with ATG [complete remission until] Oct 08 - burst blood vessels in eyes and low platelets; Jan 09 - AA & hypo-MDS; July 09 - BMT (RIC MUD PSCT) July 10 - 10k for Anthony Nolan (1yr post BMT! 53:48) Sep 10 - Wedding! I've run 5 marathons now!! (PB 3:30!)
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  #3  
Old Tue Nov 9, 2010, 08:04 PM
riccd2001 riccd2001 is offline
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McMaster Stem Cell research...

A couple of general comments from local media reports...

Time frame of about 2 years to trail phase;

Approximately 12 square centimetres for one unit of blood;

Ability of sustaining timely growth rates; and

storage/freezing possibilities.
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Ric: Low-risk MDS (blasts <4%); 4 cycles Revlimid no positive response; PRBC transfusion dependent; so far, 392'units' over 8 3/4 years; BMB #4 (15/04/01) shows evolution to AML (blasts 20-30%) 47,XY,del(5) (q22q35),+21[24][cp24]/46,XY(1).
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  #4  
Old Wed Nov 10, 2010, 11:03 AM
Lbrown Lbrown is offline
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If they can produce blood from skin, then why can't they get your marrow to produce the cells? But I agree it would be great for people who are transfusion dependent to get their own cells.

Deb
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  #5  
Old Wed Nov 10, 2010, 11:43 AM
Marlene Marlene is offline
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I know what you mean.....Why can't they take a few of your own blood stem cells and grow them....set up your own blood stem cell farm to be harvested as needed.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of January 2017, FE is 233, HGB 11.7, WBC 5.1/ANC 4.0, Plts 146K.
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  #6  
Old Wed Nov 10, 2010, 02:14 PM
Lisa V Lisa V is offline
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That opens exciting possibilities, Marlene, but their conclusion that it could make MUD BMTs a thing of the past seems like quite a leap. How would making blood from skin cells help that? They can already to autologous transplants, but I've never heard of one being done for AA or MDS.
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-Lisa, husband Ken age 60 dx SAA 7/04, dx hypo MDS 1/06 w/finding of trisomy 8; 2 ATGs, partial remission, still using cyclosporine
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Old Wed Nov 10, 2010, 02:29 PM
Marlene Marlene is offline
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Me neither....with AA, there's just not enough to harvest. I know NIH was doing a clinical trial to harvest cells of AA'er who were in remission with normal counts. You could then do an autologous BMT if they relapsed.

Having a supply of John's stem cells on hand back in 2002 would have been helpful in recovering faster from the HiCY treatment. That's the biggest risk with hicy....the length of time it takes for your BM to start producing enough stems to get you out of the danger zone.

Unfortunately, we see so many promising discoveries that go no where.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of January 2017, FE is 233, HGB 11.7, WBC 5.1/ANC 4.0, Plts 146K.
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  #8  
Old Wed Nov 10, 2010, 02:37 PM
cathybee1 cathybee1 is offline
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I was struck by the 12 square centimeters to 1 unit of blood. That's a lot of skin!
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Catherine, wife of Bruce age 75; diagnosed 6/10/11 with macrocytic anemia, neutropenia and mild thrombocytopenia; BMB suggesting emerging MDS. Copper deficient. Currently receiving procrit and neuopogen injections weekly, B12 dermal cream and injections, Transfusions ~ 5 weeks.
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