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  #1  
Old Thu Apr 14, 2016, 09:29 AM
Marlene Marlene is offline
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Ocular GVHD

Here's an article on treating ocular graft vs host disease.

https://www.sciencedaily.com/release...0413180343.htm
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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Old Thu Apr 14, 2016, 02:35 PM
Neil Cuadra Neil Cuadra is offline
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Thanks for posting this, Marlene.

It's good news that's there's an better alternative for post-transplant patients who have had to use steroids to avoid dry eyes or eye damage,
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Old Fri Apr 15, 2016, 08:35 AM
Marlene Marlene is offline
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Cyclosporine (Restasis)

I was curious to see if they did a study comparing Restasis to tacrolimus to see how they compared. I did a brief check but only found a study or two comparing them for the treatment of dry eyes and not ocular GVHD. It appears that when people cannot use Restasis anymore due to side effects, tacrolimus works for them and maybe even better.

It would be good to know if they are using Restates for GVHD now and if they compared Restasis to tacrolimus specifically for GVHD.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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Old Fri Apr 15, 2016, 12:58 PM
rar rar is offline
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I am using Restasis, FML, Muro ointment, and preservative free drops. My oncologist is not an eye doctor and my eye doctor is not an GVHD expert. I can't find a doctor who is well versed in both fields. The eyes still do what they want, sometimes pretty good and then bad.

Ray
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Old Fri Apr 15, 2016, 03:37 PM
Marlene Marlene is offline
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Here's one article looking at Restasis and tacrolimis. Seem both are pretty equally effective and tacrolimis is a good option if Restasis become problematic.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787325/
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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