Cigarette smoking shortens the survival of patients with low-risk myelodysplastic syn

[akita]

As i understood, this is only a problem for men and when they are low-risk.

I think you should read the fulltext to get more information. This has been the first lifestyle study for MDS and they supposedly have also looked for other parameters.

Kind regards, Margarete


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http://www.ncbi.nlm.nih.gov/pubmed/21287258

Cancer Causes Control. 2011 Feb 2. [Epub ahead of print]

Cigarette smoking shortens the survival of patients with low-risk myelodysplastic syndromes.

Ma X, Wang R, Galili N, Mayne ST, Wang SA, Yu H, Raza A.

Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, Box 208034, New Haven, CT, 06520-8034, USA, xiaomei.ma@yale.edu.

Abstract

Myelodysplastic syndromes (MDS) are a group of hematological malignancies with poor survival. Although previous studies have identified the prognostic role of multiple demographic and clinical characteristics, the potential role of lifestyle factors has not been evaluated. In this study, we conducted an extensive assessment of the predictors of MDS survival, with a special focus on lifestyle factors. A total of 616 patients (median survival = 4.1 years) were included in the analysis, and multivariate Cox proportional hazard models were utilized to estimate hazard ratios. Compared with non-smokers, MDS patients who smoked at the initial clinical encounter had a significantly increased risk of death [hazard ratio (HR) = 1.46, 95% confidence intervals (CI): 1.07-2.00]. The elevated risk was restricted to men (HR = 1.76, 95% CI: 1.21-2.56) and not observed among women (HR = 0.98, 95% CI: 0.51-1.85). When patients were stratified by the IPSS categorization, a near three fold increased risk of death was associated with smoking among patients with low-risk MDS (HR = 2.83, 95% CI: 1.48-5.39), whereas smoking did not appear to influence the survival of patients with intermediate- or high-risk MDS. This study was the first to identify smoking as a significant and independent predictor of MDS survival, particularly among low-risk patients.

PMID: 21287258 [PubMed - as supplied by publisher]

[Neil Cuadra]

It's not surprising that MDS patients who are smokers are at a disadvantage, since they have an added health risk, but I find it puzzling that it applies more to lower-risk MDS than to higher-risk MDS. Perhaps smokers with higher-risk MDS are more likely to stop smoking because they're undergoing more serious treatment. But why does the increased risk apply only to men?

I think this is the proposal that led to the study. It lists these factors of study: family history, medical history, cigarette smoking, alcohol drinking, exposure to occupational and environmental chemicals, and exercise.