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#1
Thu Apr 26, 2012, 04:04 PM
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New drug in trial Siltuximab
Hi all,
Now they have started a new trial for low risk MDS patients with anemia. The drug is a monoclonal antibody called Siltuximab and is targeting Interleukin-6 that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response. It is a multicenter study carried out in 48 locations in many countries. http://clinicaltrials.gov/ct2/show/N...tuximab&rank=4 Kind regards Birgitta-A 
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#2
Thu Apr 26, 2012, 04:25 PM
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I just watched a Webinar with Dr. David Steensma and he talked about this drug. Interesting about the connection between MDS and IL-6.
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Catherine, wife of Bruce age 75; diagnosed 6/10/11 with macrocytic anemia, neutropenia and mild thrombocytopenia; BMB suggesting emerging MDS. Copper deficient. Currently receiving procrit and neuopogen injections weekly, B12 dermal cream and injections, Transfusions ~ 5 weeks.
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#3
Fri Apr 27, 2012, 02:37 PM
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Thanks Brigitta, this is very interesting. Looking forward to see the results of Phase 2.
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Ric: Low-risk MDS (blasts <4%); 4 cycles Revlimid no positive response; PRBC transfusion dependent; so far, 392'units' over 8 3/4 years; BMB #4 (15/04/01) shows evolution to AML (blasts 20-30%  ) 47,XY,del(5) (q22q35),+21[24][cp24]/46,XY(1).
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#4
Fri Apr 27, 2012, 03:37 PM
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Interleukin 6 inhibitor
Hi Ric,
You know the drugs you and I have been taking - Revlimid and Thalidomide - should inhibit Interleukin 6 but they both have many other effects too. http://www.ncbi.nlm.nih.gov/pubmed/20307255 Siltuximab is supposed to inhibit Interleukin 6 without other effects as far as I understand. Kind regards Birgitta-A
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