| Home Forums |
|
|||||||
| MDS Myelodysplastic syndromes |
 |
|
|
Thread Tools | Search this Thread |
|
#1
Fri May 2, 2014, 07:43 PM
|
|||
|
|||
|
Azacitidine for treatment of imminent relapse in MDS or AML patients
Was researching this, and wondering if anyone had any thoughts...
I was offered this as a 'possible' protection against relapse, even though I am in the lowest risk band for relapse... Has anyone done this post SCT/BMT for the purpose of minimizing relapse? Background: http://www.ncbi.nlm.nih.gov/pubmed/21886171 http://www.ebmt.org/Contents/Resourc...0de%20Lima.pdf
__________________
Married, father of three daughters; now 46; diagnosed w/ Major form MDS 6/18/2013; had low counts across the board; Multiple chromosome abnormalities; Finished 2nd round Dacogen 9/13; SCT - Oct. 31, 2013; Sibling match 10/10  ; 5.5% blasts down to 3%, now 1% (post BMT)
|
|
#2
Sat May 3, 2014, 02:58 AM
|
|||
|
|||
|
I believe that Karen (handle Mausmish) was on Vidaza after transplant for either 6 months or 1 year.
__________________
MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
|
|
#3
Sat May 3, 2014, 08:53 AM
|
|||
|
|||
|
Below is another trial going on at the hospital my husband had his transplant. We've met 2 patients, one in his late 30s and another in her late teens, that are doing really well 1 year post transplant, no relapse and have participated in this trial.
http://clinicaltrials.gov/show/NCT02124174
__________________
Samantha, wife of Joe age 34; diagnosed vsaa 2012; MUD BMT February 2013
|
|
#4
Fri May 16, 2014, 10:29 PM
|
|||
|
|||
|
So I saw my Dr. today, and we further discussed Azacitidine as maintenance against relapse...
My prelim BMB results came back from my 6 month BMB, and I was still 100% Donor, no chimerism, 1% blasts, and no CD34+ expression... This along with my Myleoblative SCT, and total body irradiation (pre-SCT), leaves me with little to benefit from the chemo... We decided that since things are going so well, no maintenance treatment would be used, and unless things change, I shouldn't need it... Thanks be to God!!!! Best to all & God Bless...
__________________
Married, father of three daughters; now 46; diagnosed w/ Major form MDS 6/18/2013; had low counts across the board; Multiple chromosome abnormalities; Finished 2nd round Dacogen 9/13; SCT - Oct. 31, 2013; Sibling match 10/10 ; 5.5% blasts down to 3%, now 1% (post BMT)
|
|
#5
Sat May 17, 2014, 02:08 AM
|
|||
|
|||
|
Sounds like the right path. It is great to see you doing well!
__________________
MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
|
|
| Thread Tools | Search this Thread |
|
|
Similar Threads
|
||||
| Thread | Thread Starter | Forum | Replies | Last Post |
| Prediction of IO in MDS and AML Patients undergoing aSCT | akita | Transfusions and Iron Overload | 6 | Sat Jul 19, 2014 03:43 PM |
