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AA Aplastic anemia

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  #1  
Old Mon Jun 25, 2018, 10:08 AM
Lab2017 Lab2017 is offline
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Post BMTóBlood type not yet changing

Hello,
Iím a 40 yr old female diagnosed with Severe Aplastic Anemia 2017. I received a Bone Marrow Transplant in October of 2017. My blood type has not yet changed and Iím about 8 months post-transplant. I was told it should change about 120 days post-transplant. Has anyone else experienced this? All my blood counts are normal except my RBCs. My doctors have explained that itís not a graft failure because of this. I have to still get RBCs about every two weeks. Thanks in advance for any insight.
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Diagnosed with Severe AA in 2017; treated with hATG and cyclophosphamide; sibling 100% HLA match BMT 10/17; mother to 11 year old
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  #2  
Old Mon Jun 25, 2018, 05:24 PM
evansmom evansmom is offline
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Hi there.

My son's blood type (O+) didn't change to donor blood type (A+) until about 8 months post transplant. From what I have read, some type transitions take longer than others.

Are your docs certain you are not experiencing some hemolysis? Cyclosporin and tacrolimus can cause this, though it's rare. My son had that too. It's called Transplant Associated Microangiopathy (he was on Tacrolimus and switching him to MMF was the remedy).
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Nicole, mom to Evan (20); diagnosed SAA November 2007, hATG mid-November 2007, no response after 6 months, unrelated 9/10 BMT June 2008, no GVH, health completely restored thanks to our beloved donor Bryan from Tennessee.

www.caringbridge.org/visit/evanmacneil
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  #3  
Old Tue Jun 26, 2018, 08:57 PM
Lab2017 Lab2017 is offline
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Thank you. This gives me hope! What is MMF? Iíd like to ask my doc about it. Iím glad your son is doing so well now.
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Diagnosed with Severe AA in 2017; treated with hATG and cyclophosphamide; sibling 100% HLA match BMT 10/17; mother to 11 year old
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  #4  
Old Tue Jun 26, 2018, 08:59 PM
Lab2017 Lab2017 is offline
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Oh I failed to mention that is the exact switch Iím waiting foróO+ to A+
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Diagnosed with Severe AA in 2017; treated with hATG and cyclophosphamide; sibling 100% HLA match BMT 10/17; mother to 11 year old
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  #5  
Old Tue Jun 26, 2018, 11:18 PM
lisa3112 lisa3112 is offline
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I am 2 years post transplant! My donors blood type is A+ and I am O+.... still O+ now! I am really well (touch wood) and my heamatologist said it is rare, but not much to be done really. I have 100% Chimarism too.
I dont understand how I am complete donor, but I'm producing O+ blood.
Anyway good to know I'm not alone.
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Now 30yr old. Diagnosed AML dec 2015 (Most likely MDS prior). Trisomy 6. Runx1 mutation also. Had induction and consolidation chemo. Marrow failure ++ so SCT on 21st of March with MUD. Married with a 1yr old!
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  #6  
Old Thu Jun 28, 2018, 08:05 AM
Lab2017 Lab2017 is offline
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Glad to here Iím not alone either lisa3112. Also glad to hear you are doing well. Take good care.
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Diagnosed with Severe AA in 2017; treated with hATG and cyclophosphamide; sibling 100% HLA match BMT 10/17; mother to 11 year old
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