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Transfusions and Iron Overload Blood and platelet transfusions, iron testing and treatments

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  #1  
Old Wed Jan 3, 2007, 08:11 PM
kvichi kvichi is offline
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platelet transfusions

Hi everyone,
When my father went in for his 2nd round of Vidaza, he was told his platelets were too low to give the treatment so instead he received a platelet transfusion. His platelets were at 10. I thought I had read somewhere that platelet transfusions don't last long and can only be given a few times before they become obsolete. Is this right? Does anyone have insight into this?

thanks,

Kim
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  #2  
Old Thu Jan 4, 2007, 12:32 AM
Wendy Beltrami Wendy Beltrami is offline
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Kim,
The concern with platelet transfusions is that the patient will become allo-immunized or refractory to them. Meaning that the patient will no longer gain any benefit from transfusions. This could obviously be very dangerous if the patient could not gain any benefit from a platelet transfusion if they were having serious bleeding.

Requesting single donor platelets bags rather than pooled donors helps to minimize this risk since you are exposing yourself to fewer donors.

I understand that some people become allo immunized quickly and some are lucky enough to endure many platelet transfusions without becoming refractory. My son has had 32 units. So far, so good.

Wendy/mom to Grant
dx 12/4/98 AA
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  #3  
Old Thu Jan 4, 2007, 11:49 PM
Steve Kessler Steve Kessler is offline
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Question Platelet lifetime

My doc said the same thing and I posted his opinion, Several people responded that they had been receiving platelets for extended times with no dimiuttion of efficacy. Evidently, some people buid up antibodies quickly while others don't.
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Steve Kessler,Age 71, Dx 3/2001, Currently AML converted from MDS, 5q-, 11q23, Negative response to Aranesp, Revlimid. Partial response to Vidaza in the past. On a study using ON1910.NA, counts too low to go to Stanford on schedule.
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  #4  
Old Fri Jan 5, 2007, 08:51 AM
Bruce Lande Bruce Lande is offline
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Platelets duration and risk

Transfused platelets usuallly only last 2-3 days (I think I may have gone 5-6 days at best when I was platelet transfusion dependent) and must be used within 5 days of being drawn (RBC's can be stored for 42 days). According to an AAMDS article I found, "the immune system can eventually learn to recognize and destroy transfused platelets."
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https://aplastic.livejournal.com/18236.html
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  #5  
Old Fri Jan 5, 2007, 10:46 AM
Marlene Marlene is offline
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John had so many platelet transfusions over 20 months that I lost count. He had well over 200 and never became refractory. But towards the end, as his immune system improve, he was getting hives more often even with pre-meds.

Marlene
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  #6  
Old Fri Jan 5, 2007, 11:33 PM
george peveto george peveto is offline
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there is some benefit to receiving irradiated platelets I believe that radiating the platelets prevent problems in the future you may want to research that to determine if you want to ask your doctor to provide you with irradiated platelets I think it has to do with less problems when and if you do receive a transplant and may also be helpful with reaction to platelets from several donors
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