Home         Forums  

Go Back   Marrowforums > Bone Marrow Failure Diseases > MDS
Register FAQ Search Today's Posts Mark Forums Read

MDS Myelodysplastic syndromes

Reply
 
Thread Tools Search this Thread
  #1  
Old Tue Mar 22, 2011, 03:01 AM
Neel Neel is offline
Member
 
Join Date: Dec 2010
Location: delhi india
Posts: 73
difference in lab reports

I was just wondering if u guys have ever experienced the difference in lab reports. I have been facing this for quite some time now. When ever i send the sample of blood for CBC to 2 labs, i get different readings. Lately the difference in readings have been quite vast. I sent the sample to two lab on 17/3/11 and one lab showed the platelet count as 30000 and other as 15000. next day i.e. 18/3/2011 when i repeated the CBC, the reading was 25000 and 22000. I got the CBC done ysday i.e. 21/3/2011 and the results 58000 and 12000.

If i go by report of one lab we have to consider transfusion of platelet (12000 is the count of that lab) and other lab is showing 58000, therefore no need of transfusion. its kind of confusing. The treatment of this disease depends on reports, and if the reports are so contradictory then ????

Neel

P.S. No use in talking to the lab people as they swear by there report. In fact i did talked to both the lab people with no outcome, both sweared by their report.
__________________
Father age 64 diagnosed with MDS RAEB-2, with 15%-18% blasts in October 2010. Only had blood and platelet transfusions. Ayurvedic treatment which showed result for arnd 5 months. Started Tahlidomide 100 mg started on 22 nd April 2011. Revolade 50 mg started on 2 nd april 2012.
Reply With Quote
  #2  
Old Tue Mar 22, 2011, 05:21 AM
Chirley Chirley is offline
Member
 
Join Date: Oct 2007
Location: Logan City Australia
Posts: 1,100
Hi

Beat this. I had 2 blood request forms but had them both at the one lab at the same time. The nurse took the blood from the same puncture with the same needle and just placed the blood into the 2 different tubes. The results were quite different to each other.

The doctor didn't care, he just shrugged and said that "it happens"

Good luck. Perhaps you should take the mean value of the 2 as correct.

Regards
__________________
Copper deficiency bone marrow failure (MDS RAEB 1), neuromyelopathy.
FISH reported normal cytogenetics but gene testing showed
Xq 8.21 mutation
Xq19.36 mutation
Xq21.40. mutation
1p36. Mutation
15q11.2 deletion
Reply With Quote
  #3  
Old Tue Mar 22, 2011, 07:12 AM
Paula W. Paula W. is offline
Member
 
Join Date: Dec 2010
Location: Jackson, NJ
Posts: 61
Hi Guys,

My Mom is having the same issue. Not so much in the same day, but from 1 day to the next. Last week she went for blood on a Wednesday and platelets were 35,000, next day on Thursday 17,000, and then on Friday before her transfusion she went back up to 27,000 and they cancelled the transfusion.

I agree with you, how do you treat when the blood is so inconsistent?

Best to all!

Paula
Reply With Quote
  #4  
Old Tue Mar 22, 2011, 07:51 AM
Marlene Marlene is offline
Member
 
Join Date: Oct 2006
Location: Springfield, VA
Posts: 1,412
This is true for most. The equipment used to automatically count your platelets and red cells are calibrated to look at the size of the cell to include in the count. If the platelet is larger or smaller than what the machine counts, then those cells are excluded. However, the gap between labs should not be too wide. 5K is not a wide gap. But it is everything for someone with almost no platelets. Some labs automatically re-check low platelet counts manually when the machine count is below a certain number. That would be stated on the lab report.

What you need to do is to decide on just one lab to manage your transfusions and track your trends. And then take into account your symptoms. With John, we kept pushing the threshold. Instead of going by "standard threshold", we found the lowest level he could go without symptoms. So he would get platelet transfusions at 8K or at anytime where he was bleeding more than usual.

The other thing that can effect the count is how the specimen is handle either during the draw or at the lab.

Platelets fluctuate daily and it's not unusual for them to bounce around. So I wouldn't worry too much about the changes from one day to the next.

Managing this disease is as much an art as it is a science. You cannot go by test results exclusively.
__________________
Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Difference between "immature granulocytes" and ... bailie MDS 4 Sat Mar 28, 2015 10:09 PM
difference between 8/8 and 10/10 match. pdiitdelhi0204 Transplants 1 Tue Apr 1, 2014 01:40 PM
Difference between MDS and CMMOL ?? annmonster MDS 2 Tue Dec 20, 2011 07:55 PM
A special forum for reports from clinical trials Birgitta-A Site Comments 2 Sun Oct 14, 2007 01:43 PM


All times are GMT -4. The time now is 08:52 PM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright © 2006-2020 Marrowforums.org