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#1
Tue Aug 5, 2014, 07:22 PM
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BMB 1 Month post transplant question
I got my BMB report and I don't know what to think of it. On one hand it says No molecular evidence of residual host pre-transplantation cells is detectable, but host alleles are 12 to 32%.
My ANC went from 0 to 3.2, WBC went from 0 to 4.1 the highest they have been since a year before I was diagnosed with MDS. Hemoglobin from 7.8 to 11.4, and platelets from 11 to 57, had been as high as 75. These numbers seem encouraging. Ray INTERPRETATION: Donor cells constitute approximately 68% of the cell population in the CD3-enriched cell fraction, approximately 75% of the cell population in the CD33-enriched fraction and approximately 88% of the CD56-enriched fraction of the peripheral blood specimen from 07-30-14. CHIMERISM MULTISPEC RESULTS: Donor Alleles Host Alleles Specimen: CD3 fraction Detected (Approx 68%) Detected (Approx 32%) Specimen: CD33 fraction Detected (Approx 75%) Detected (Approx 25%) Specimen: CD56 fraction Detected (Approx 88%) Detected (Approx 12%) INFORM: The STR markers are informative for both the pre-BMT host and donor genomic DNA and can be used to monitor bone marrow transplant engraftment. NONINFOR: The STR markers would not be useful for monitoring bone marrow transplant engraftment. NOMOLEC: No molecular evidence of residual host pre-transplantation cells is detectable by PCR in this specimen. 
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#2
Tue Aug 5, 2014, 08:53 PM
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rar,
Obviously it shows chimerism of 68%/32% (Donor/your old cells), which at 30 days may not be bad in itself, but interpretation of the results really should be left to your doctor to explain to you.. Wishing you only the Best, and speedy 100% engraftment... May God Bless us ALL!!!
__________________
Married, father of three daughters; now 46; diagnosed w/ Major form MDS 6/18/2013; had low counts across the board; Multiple chromosome abnormalities; Finished 2nd round Dacogen 9/13; SCT - Oct. 31, 2013; Sibling match 10/10  ; 5.5% blasts down to 3%, now 1% (post BMT)
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#3
Wed Aug 6, 2014, 06:59 PM
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Great to see you post Ray. How are you feeling??. Your counts look great.
Your Doc will know how to interpret it. I see 3 different stains with one showing 88% donor. Specimen: CD3 fraction Detected (Approx 68%) Detected (Approx 32%) Specimen: CD33 fraction Detected (Approx 75%) Detected (Approx 25%) Specimen: CD56 fraction Detected (Approx 88%) Detected (Approx 12%) But more importantly: NOMOLEC: No molecular evidence of residual host pre-transplantation cells is detectable.
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#4
Wed Aug 13, 2014, 01:42 AM
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Keep up the good work!
Yes, your labs look encouraging for day 30 + !
Follow your medical advise, keep clean, stay away from others , take your meds as directed, exercise as tolerated daily, keep your weight stable now is not the time to loose weight. Be joyful you are doing so well! Excited for you!
__________________
Kris, wife of Rick. DX; MDS/ Ringed Siderblast 5/2006. Supportive care, then Vidaza x 25 mo. HSCT 11//1/11 doing GREAT!
Last edited by kris : Wed Aug 13, 2014 at 01:44 AM. Reason: spelling
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#5
Wed Aug 13, 2014, 05:12 AM
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SCT
Congratulations Ray!
Kind regards Birgitta-A
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