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  #1  
Old Wed Jul 7, 2010, 07:41 PM
mausmish mausmish is offline
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Question How did you choose your transplant center?

This is directed to those who've had BMT's or are awaiting BMT's. How did you choose your transplant center? Did you choose the nearest? Did you look for one that had better success stats or more cases similar to yours despite others being nearer? Did you visit many centers before you chose? Anything else that went into your choice? Thanks!
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #2  
Old Thu Jul 8, 2010, 07:14 AM
squirrellypoo squirrellypoo is offline
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My experience probably won't be very helpful for you since the UK's leading specialists and researchers in AA and MDS (Prof Marsh and Mufti) were at King's, which is right around the corner from where I live. And Kings do more transplants than anywhere else in the UK (and one of the top centres of the world) so I didn't even consider going anywhere else. It was really, really nice being so close to family and friends, as it meant lots of people could just pop in to keep me company without having to stay in a hotel.

Being nearby also meant that I could live at home for a long portion of my post-transplant time - at one point I was ONLY released from hospital because I promised to come in to outpatients every single day (M-F) for an IV drip, which ended up carrying on for a full six months. So as hard as the daily commute was (my fiance had to drive me in since you can't use public transport), it was lightyears better than being in a ward for that time.

So if you need to have your transplant far away from your home, realise that you'll need somewhere to stay in the area for several months after the transplant itself, whether that's with friends or at an extended stay hotel. My 6 months of daily appointments was a bit unusual, but it's nothing to go in 3 times a week for 2-3 months post-transplant.
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36/F - 1984 SAA treated with ATG [complete remission until] Oct 08 - burst blood vessels in eyes and low platelets; Jan 09 - AA & hypo-MDS; July 09 - BMT (RIC MUD PSCT) July 10 - 10k for Anthony Nolan (1yr post BMT! 53:48) Sep 10 - Wedding! I've run 5 marathons now!! (PB 3:30!)
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  #3  
Old Thu Jul 8, 2010, 08:46 AM
starz starz is offline
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I also am from UK. I found the top MDS specialist in the country, in the top hospital and asked for a referral for my husband.
It isnt close for us, so we did a lot of travelling. I have rented a flat as he has just had the transplant, and we will stay close by for 3-4 months.
My logic was to just go to the top, and even if it will cost more in time and money, you will never be able to say 'I wish we had gone there'.
Starz
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  #4  
Old Thu Jul 8, 2010, 11:37 PM
Neil Cuadra Neil Cuadra is offline
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Karen,

I suggest that you take a look at the "Choosing a Transplant Center" page of the National Marrow Donor Program. They give guidance about what to look for and provide statistics about transplant centers.
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  #5  
Old Sat Jul 10, 2010, 12:45 AM
mausmish mausmish is offline
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Thanks, Neil. I'd been through all the literature. I was more interested in people's personal stories. I know in the end everyone's circumstances are different but I love hearing the anecdotal accounts from the different perspectives.
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #6  
Old Sat Jul 10, 2010, 03:54 PM
Laura Laura is offline
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Hello,

I debated for a long time between Seattle and my own health care provider Mayo Clinic. I went back and forth. Seattle did the most transplants and had the best doctors for AA. However, Mayo Clinic was close to my house, home, family, and support system. When it came down to it, having my home and support system close by was one of the major reasons why I choose Mayo. I also was very comfortable with the physicians and their plan of care. They were having a trial using Campath instead of ATG. I wasn't keen on using ATG. I had done it twice within the previous 9 months and I had reacted pretty bad both times. I just felt very comfortable with the care and the staff. Going through the transplant, I was so thankful to have my family and friends around. They were valuable and more valuable then I have thought prior to transplant. I am so thankful that I did my transplant here and would do it again without a second thought. Sometimes having the best physicians and the best place isn't always enough. It's nice to have your home, family, and friends too.

Laura
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Laura; dx SAA; MUD transplant June 18, 09; ITP June, 2011; fighting multiple complications/GVHD and now low counts again...
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  #7  
Old Sat Jul 10, 2010, 04:42 PM
mausmish mausmish is offline
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Hi Laura - I know what you mean. I'm still undecided but am leaning toward close to home with Johns Hopkins or University of Maryland. I'm also getting a consult at The Hutch in Seattle next month. Thanks for your reply. Karen
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #8  
Old Tue Aug 10, 2010, 09:29 PM
Jayceechic Jayceechic is offline
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I was only recently diagnosed with MDS so I'm in the process of researching locations. I live in Maryland and was treated at NIH for NHL in 2007, but since I found out today my brother isn't a match I have to look at other options since NIH doesn't perform un-related transplants. I'm looking at Hopkins, based on a co-workers recommendation and experience, and MD Anderson in Houston because I have family there and because they are supposedly a good transplant hospital. Based on a recommendation from another transplant survivor who had a MUD BMT, I'm also considering Baylor in Dallas.

I'm overwhelmed with my choices and my head hurts from thinking about it all. What if I make the "wrong" choice.
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Angela; diagnosed NHL April 2007 -treated w/6 cycles EPOCH; diagnosed MDS July 2010; currently looking for BMT match
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  #9  
Old Tue Aug 10, 2010, 11:51 PM
Laura Laura is offline
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I use to worry about making the wrong decision in regards to choosing a place for transplant. But now I can honestly saw there is no wrong decision. If you do your research and pick a place based on where you thought was best, then you are making the right decision. You will never know all the what ifs and so you just need to make the decision based on what you think is best and don't look back on that decision.

This probably doesn't make sense but it does in my head

Laura
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Laura; dx SAA; MUD transplant June 18, 09; ITP June, 2011; fighting multiple complications/GVHD and now low counts again...
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  #10  
Old Wed Aug 11, 2010, 01:28 AM
Neil Cuadra Neil Cuadra is offline
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Angela,

For considering where you might get a transplant, I suggest that you take a look at the advice on Choosing a Transplant Center from the National Marrow Donor Program. They'll be the ones looking for a matched donor for you, since unfortunately your brother didn't match you. They have posted the number of transplants done by each center and other statistics that can help you narrow down your choices.

Check with your medical insurance company to see if you are covered even if you go to an out-of-state transplant center, and whether there are any restrictions on coverage you need to know about.

Being near home or family is important so I'm glad you are considering that factor. If it will help, look at the Treatment Center Map we've provided for patients, to see where some of the treatment centers likely to have experience treating MDS are located.
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  #11  
Old Wed Aug 11, 2010, 11:28 PM
Debbie W Debbie W is offline
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Karen

My husband really wanted to stay closer to home and that definitely had an influence, so we have stayed with Sloan as opposed to going across country to Seattle or even to the NIH. He is now undergoing induction therapy at Sloan and then hope to move to transplant in late September or early October if his blast count is under 5%. Please post about your consultation in Seattle.

Thanks in advance and best wishes,

Debbie
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Debbie, wife of Mike age 58, diagnosed RAEB 2 April 2010. Initial blast count somewhere between 10-15% then 20% after two treatments of Dacogen. Completed induction therapy 8/2/2010. BMB 8/31/10 - 4% blasts. SCT 10/1/2010. Relapsed in 10/2014, second transplant from same donor on 12/31/2014.
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  #12  
Old Thu Aug 12, 2010, 11:36 PM
mausmish mausmish is offline
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I just got the results from my bmb after 7 months of Vidaza. My blasts are still holding at slightly over 5% and i still have the complex chromosome abnormalities but they are affecting only 1 cell in 20 as opposed to 14 in 20 before. My blasts were 17-20% when first diagnosed in January. I don't have a donor yet so am relieved to be holding steady. I've gotten my consultation with The Hutch all lined up for the 24th and for Johns Hopkins as soon as my slides are returned from Seattle. I definitely understand the feeling of being overwhelmed with the weight of the decision. Laura, i love the wisdom of your words. Thank you. I'll let you know my impressions after the consults. One thing I feel better about already is that my local hematologist and my oncologist at University of Maryland are both extremely supportive of my decision to seek additional opinions. I like and respect them both and didn't want them to feel offended. They both said for a life altering decision like this, it makes sense to explore different options. They're also both thrilled with my progress with Vidaza. Initially, my prognosis looked very poor. Don't ever give up hope.
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #13  
Old Fri Aug 13, 2010, 05:25 PM
Laura Laura is offline
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Karen,

Please do let me know how the consults go. I will be thinking of you. Glad I could help.

So glad to hear your blasts are down and your cells are looking better!!

It is great that your local physicians are supportive of second opinions. It makes it easier to continue to see them while you are searching for your answers of where to go.

Please let me know if you have any other questions.

Laura
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Laura; dx SAA; MUD transplant June 18, 09; ITP June, 2011; fighting multiple complications/GVHD and now low counts again...
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  #14  
Old Tue Sep 7, 2010, 07:41 PM
mausmish mausmish is offline
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Had consult in Seattle

I live in Maryland and am currently being treated through University of Maryland. For my MUD SCT/BMT, I'm also considering Johns Hopkins because it is an excellent center and close to home and The Fred Hutchinson Center in Seattle because they were the first to do the procedure and do many each year. Also, they come highly recommended by many long term survivors.

I had my consultation in Seattle a couple of weeks ago, and it went very well. The staff was friendly, timely, and knowledgable, and the facilities beautiful. The doctor spent 90 minutes with my husband and me and answered most of our questions without our even having to ask. It was apparent he had reviewed my records and slides and familiarized himself with my case before we got there. They have a couple of promising clinical trials for which I might be eligible that are not available closer to home.

My appointment at Johns Hopkins is Sept. 23, after which I'll make my decision about where to go (assuming I'll be abe to find a donor!). The decision will be difficult but i feel very fortunate that I have so many good alternatives to choose among!
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #15  
Old Tue Sep 7, 2010, 09:40 PM
Laura Laura is offline
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Hi Karen,

So glad to hear your consultation went well! That is exciting about the clinical trials you could possible be in. What are the advantages to the clinical trials? What are they trying to "find", "improve", "make better", or I guess I mean, what are they trying to research specifically with the trials you were looking at. Are they brand new trials? Have they had success so far? Just different things to think.

I did a trial that Mayo was doing. I am so happy I did the trial and would do it over again if I had to.

I had a very hard time choosing between the two places. I never did an official consultation at Seattle. I did do a phone consultation.

Do you have anything that you are looking at specifically in deciding?

Do you have a website or anything you update?

But do keep us updated here too.

Laura
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Laura; dx SAA; MUD transplant June 18, 09; ITP June, 2011; fighting multiple complications/GVHD and now low counts again...
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  #16  
Old Thu Sep 9, 2010, 12:22 PM
mausmish mausmish is offline
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Hi Laura,

I'm not looking at any specific criteria in a transplant center but rather am looking with an open mind at what each facility has to offer that might be relevant to my particular case. Since I'm within an hour of the renowned Johns Hopkins, it made sense to look there. University of Maryland is also very good and equally close - my hematologist sent me there initally because they could see me more quickly, and I was at a critical stage then (before the Vidaza treatments). Seattle came so highly recommended by many that I wanted to give it a try, not to mention that it was a great place for a summer vacation.

My doctors are concerned about my being at high risk for a post transplant relapse due to the nature and number of my chromosome abnormalities. The trial offered at The Hutch in Seattle uses targeted radioactive antibodies for pre-transplant conditioning to deliver a higher dose of therapy directly to the diseased cells in the marrow and spleen while tryng to minimize the risk to other organs. The procedure is very interesting and is not offered anywhere else. I'm definitely considering participating but want to first see what Hopkins has to offer. The obvious drawback to Seattle is the distance from home!

If only we could know how long the Vidaza will continue working, it would be great to be able to wait another year to see what new treatments are on the horizon! However, all of the doctors I've talked to so far are urging me to move forward with the transplant soon while I'm in partial remission (blasts at 5-8%). There's no way of knowing how long this will last.

I do have a Caring Bridge page but it has not been kept up to date. My most current info is here.

Thanks for your interest, and I hope you're doing well!

Karen
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #17  
Old Thu Sep 9, 2010, 04:32 PM
Debbie W Debbie W is offline
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Karen

Thanks for the update on your transplant center search. Glad to read that you have had good success with the Vidaza in reducing the blast count, wishing you continued success.

Best regards,
Debbie
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Debbie, wife of Mike age 58, diagnosed RAEB 2 April 2010. Initial blast count somewhere between 10-15% then 20% after two treatments of Dacogen. Completed induction therapy 8/2/2010. BMB 8/31/10 - 4% blasts. SCT 10/1/2010. Relapsed in 10/2014, second transplant from same donor on 12/31/2014.
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  #18  
Old Thu Sep 9, 2010, 04:54 PM
Laura Laura is offline
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Karen,
Wow that trial sounds really, really interesting!!

Thanks for the info, it was great to read.

Yes, if only we could see the future, oh how that would help us decide many things when it comes to this disease!

Sounds good on the CB site, glad you keep us updated on here then

Laura
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Laura; dx SAA; MUD transplant June 18, 09; ITP June, 2011; fighting multiple complications/GVHD and now low counts again...
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  #19  
Old Fri Sep 10, 2010, 09:45 PM
mausmish mausmish is offline
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Caring Bridge Site

I have posted my background story and some photos if anyone wants to put a face to a name.

http://www.caringbridge.org/visit/mausworks

Karen
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #20  
Old Fri Sep 10, 2010, 11:43 PM
Debbie W Debbie W is offline
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Karen

Thanks for the link and for updating us on your search for a transplant center.

Best regards,
Debbie
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Debbie, wife of Mike age 58, diagnosed RAEB 2 April 2010. Initial blast count somewhere between 10-15% then 20% after two treatments of Dacogen. Completed induction therapy 8/2/2010. BMB 8/31/10 - 4% blasts. SCT 10/1/2010. Relapsed in 10/2014, second transplant from same donor on 12/31/2014.
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  #21  
Old Sat Sep 11, 2010, 10:00 AM
Susan L Susan L is offline
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Karen -

"If only we could know how long the Vidaza will continue working, it would be great to be able to wait another year to see what new treatments are on the horizon! However, all of the doctors I've talked to so far are urging me to move forward with the transplant soon while I'm in partial remission (blasts at 5-8%). There's no way of knowing how long this will last."

Karen - I read your story and am happy for the success you are making on the Vidaza ad I also am on Vidaza and just finished 9/3. I too have multiple chromosome changes and blasts now are only 5 - 6 %. The only side effects so far for me are still tiredness but no way as much as w/Dacogen. I am not scheduled for any other treatment except for the Vidaza to see what happens. Do you have a family member for the SCT? I wish you continued success.
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Susan Patient, 58, MDS, UPDATED 9/13
Now have RAEB-2, Firbrosis 3+, blasts 18% peripheral, 10 - 14% blasts marrow, chromosomes now T 1:21, trisonomy 16 and 1.- Match found ---10/10 -couldn't believe when I heard - Tentative day is 1/09th!!!! Admit date changed to 11/12. WOW -
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  #22  
Old Sat Sep 11, 2010, 11:04 AM
mausmish mausmish is offline
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Thanks, Susan. Happy to hear your 1st Vidaza cycle went well! I am a little tired, too but not bad. I don't have a related donor, am in process of seeking MUD. Where are you being treated? (sorry I don't remember.)
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #23  
Old Sat Sep 11, 2010, 03:37 PM
Susan L Susan L is offline
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Karen

Quote:
Originally Posted by mausmish View Post
Thanks, Susan. Happy to hear your 1st Vidaza cycle went well! I am a little tired, too but not bad. I don't have a related donor, am in process of seeking MUD. Where are you being treated? (sorry I don't remember.)
Hi - I am being treated by GA Ca Specialists here in Athens, GA. They are a fantastic group I was fortunate to get with. 7 yrs ago I had treatment at the NIH w/Dr Sloan. ATG treament that lasted till this past April. I also did not have any chromosome abnormalities then, now I have multiple chromosome abn. My report said that there wasnt any normal ones in the specimen received. Still all confusing to me. May I ask - what insurance do you have?
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Susan Patient, 58, MDS, UPDATED 9/13
Now have RAEB-2, Firbrosis 3+, blasts 18% peripheral, 10 - 14% blasts marrow, chromosomes now T 1:21, trisonomy 16 and 1.- Match found ---10/10 -couldn't believe when I heard - Tentative day is 1/09th!!!! Admit date changed to 11/12. WOW -

Last edited by Susan L : Sat Sep 11, 2010 at 03:56 PM.
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  #24  
Old Sat Sep 11, 2010, 05:30 PM
mausmish mausmish is offline
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Susan, i am fortunately double insured, United Healthcare and Tricare standard. Regarding the chromosome abnormalities, it sounds like you're talking about the number of cells affected rather than the number of abnormalities (or perhaps both). For example, in my first biopsy I had 14 out 20 cells that were abnormal. Each of those 14 cells had multiple abnormalities such as 5q deletion, trisomy 8, and several others as well as an unknown marker. When I had my biopsies redone 3 months and six months later, only 1 cell in 20 was abnormal but that cell had all the same chromosome abnormalities as before. I was very confused initially because I'd never heard of any of this. I got a copy of my cytogenetic report and then found a site online that explained how to read it, which helped a lot. I still find the reports difficult to read because of the medical jargon. I'm a math/computer geek so this is alien to me.

It's great that you have a team of doctors you're comfortable with. That's so important. I've been fortunate in that respect, too.
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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  #25  
Old Sun Sep 12, 2010, 01:06 AM
Debbie W Debbie W is offline
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Karen

If you still have the link that helped decipher the BMB report would you post it for me and possibly others as well.

Thanks,
Debbie
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Debbie, wife of Mike age 58, diagnosed RAEB 2 April 2010. Initial blast count somewhere between 10-15% then 20% after two treatments of Dacogen. Completed induction therapy 8/2/2010. BMB 8/31/10 - 4% blasts. SCT 10/1/2010. Relapsed in 10/2014, second transplant from same donor on 12/31/2014.
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