Home         Forums  

Go Back   Marrowforums > Bone Marrow Failure Diseases > AA
Register FAQ Search Today's Posts Mark Forums Read

AA Aplastic anemia

Reply
 
Thread Tools Search this Thread
  #1  
Old Wed Nov 26, 2014, 12:05 PM
StephM StephM is offline
Member
 
Join Date: Oct 2013
Location: France
Posts: 19
AA and hip replacement

Hi!
I have read a few things on this forum about avascular necrosis and hip replacement due to high doses of corticosteroids but none actually answered my question.
To make it short, my brother is 12 months after horse ATG and his counts are close to normal. He still has a low dose of cyclosporin.
Severe hip pain. MRI showed osteonecrosis in both hips with edema and he needs protheses.
My question is about the potential danger of undergoing surgery and taking new medicine now. Is there a risk of AA relapse?
Thanks
__________________
Steph, 25yo brother diagnosed with AA July 2013. Horse ATG Sept, currently on cyclosporin
Reply With Quote
  #2  
Old Thu Nov 27, 2014, 03:18 AM
Neil Cuadra Neil Cuadra is offline
Owner
 
Join Date: Jul 2006
Location: Los Angeles, California
Posts: 2,553
Steph,

I can't see how surgery could harm his bone marrow, so AA relapse shouldn't be a concern. Surgery can be risky if blood counts aren't high enough, but since your brother's counts are almost normal he'd likely be cleared for surgery.

Surgeons need to know about all of the medicines a patient is taking, and the status of all of their health conditions. A patient's hematologist should give an OK before surgery.
Reply With Quote
  #3  
Old Thu Nov 27, 2014, 06:39 AM
StephM StephM is offline
Member
 
Join Date: Oct 2013
Location: France
Posts: 19
Thank you very much for your answer!
We had not seen that coming... That's how you realize the treatments for AA are incredibly aggressive too
Let's hope that after the hip replacement, we will be done with pain, doctors and hospitals for a very long time...
__________________
Steph, 25yo brother diagnosed with AA July 2013. Horse ATG Sept, currently on cyclosporin
Reply With Quote
  #4  
Old Thu Nov 27, 2014, 05:55 PM
Hopeful Hopeful is offline
Member
 
Join Date: Jan 2009
Location: California, USA
Posts: 766
Unfortunately, I have heard the opposite...

I was told that surgery itself is a major stress for the immune system and can trigger a relapse. I met someone at one of the conferences with AA that relapsed after a knee replacement.

It doesn't happen to everyone, but be vigilant afterwards.
__________________
55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
Reply With Quote
  #5  
Old Sun Nov 30, 2014, 10:28 AM
StephM StephM is offline
Member
 
Join Date: Oct 2013
Location: France
Posts: 19
Thanks for the warning.
I will try to browse the net for information about that.
We are meeting the doctors on Friday. There will be an hematologist and an orthopedist. I will try to ask them but they probably don't know anything.

My brother seems to be the 2nd or 3rd patient with AA that has been treated in this hospital. So probably the 1st one who will need surgery after the treatment...

He was slowly tapering cyclosporin and is currently on a low dose; the last step before stopping it completly. This should have been next month.Probably the time when he will be operated on.
I wonder if it wouldn't be safer to keep the low dose a little longer.
__________________
Steph, 25yo brother diagnosed with AA July 2013. Horse ATG Sept, currently on cyclosporin
Reply With Quote
  #6  
Old Fri Dec 12, 2014, 02:06 AM
Susan Susan is offline
Member
 
Join Date: Sep 2003
Location: Chicago, Il
Posts: 101
I had a hip replacement, no problems. But my plts were 120, whites and ANC not very bad. Whites were in 2s, ANC around 1.2. Post surg no AA count decline, had it done on 2009.

I wasn't on Clyclo and had not had ATG. I had been on Prednisone many years. One ortho told me it was osteonecrosis. The other Ortho said no, definitely not but osteoarthritis. Either way it was easier and less painful than I expected. Just took a short course of antibiotics and morphine.

But just ask a couple of good hems, they should know the answers.

Now I need the other side done but can't since my ANC way too low. In my view get it done if counts reasonable in case they drop and it's too late then. I'm stuck limping and using a cane.
__________________
AA/PNH Dx 1998, Warfarin, Soliris
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
16 years post unrelated bone marrow transplant for AA MichyJ Tell Your Story 4 Wed Sep 26, 2012 07:41 AM
I am an AA spouse and new to this site.... trialad2 AA 9 Tue Apr 7, 2009 02:23 PM


All times are GMT -4. The time now is 08:11 AM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright © 2006-2020 Marrowforums.org