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Transfusions and Iron Overload Blood and platelet transfusions, iron testing and treatments

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  #1  
Old Thu Dec 16, 2010, 02:12 PM
akita akita is offline
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Prediction of IO in MDS and AML Patients undergoing aSCT

http://ash.confex.com/ash/2010/webpr...aper31120.html

3493 Comparing the Value of Serum Ferritin, Transfusion History and Magnetic Resonance Imaging for the Prediction of Iron Overload In MDS and AML Patients Undergoing Allogeneic Stem Cell Transplantation

"Our data suggest that serum ferritin or transfusion history cannot be regarded as robust surrogates for the actual iron overload in MDS or AML patients. Therefore we advocate caution when using one of these parameters as the only trigger for chelation therapy or as a risk-factor to predict outcome after allo-HSCT."
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  #2  
Old Tue Jul 15, 2014, 07:56 PM
usaf1125 usaf1125 is offline
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Iron overload

I have been getting transfusions for 10 years, so far I have had 384 units of PRC I take nothing for the Iron, my level is always off the charts, 2500+. I haven't had a adverse reactions, I'm not rusting, my Dr. is OK with it.
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82 yr. old male. Diagnosed in 2003. Started Blood infusion 1/5/2004, average of 2 units every 2 weeks. Inject Procrit weekly 40,000 ML. I have had 344 units of PRC. E Mail leojean@comcast.net
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  #3  
Old Wed Jul 16, 2014, 11:20 AM
Mseth Mseth is offline
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10 yrs of transfusions

Hi usaf1125,

My mother is on a supportive care regime of pRBC transfusions for last 16 months, almost 40 units so far, averaging 2 units every 3 weeks.
Have you had prolonged spells of low grade fevers? She is currently battling a fever for last few weeks without any conclusive diagnosis on the cause. Maybe it is because of mds.
Have your other counts- whites and platelets remained stable in these last 10 years?

Thanks in advance for your reply.
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Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
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  #4  
Old Wed Jul 16, 2014, 01:23 PM
usaf1125 usaf1125 is offline
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iron overload

all my numbers vary, sometimes normal, sometimes high, sometimes low. When I first started I got a fever after an infusion. they started to pre med me with, Tylenol, Benadryl, and Hydrocortisone, that took care of the fever. It is a very strange disease.
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82 yr. old male. Diagnosed in 2003. Started Blood infusion 1/5/2004, average of 2 units every 2 weeks. Inject Procrit weekly 40,000 ML. I have had 344 units of PRC. E Mail leojean@comcast.net
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  #5  
Old Thu Jul 17, 2014, 02:34 PM
Mseth Mseth is offline
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MDS

Hi usaf1125,

Thanks for your reply.

Yes, no doubt MDS is a strange disease.

Doctor is ok with premedicating with Tylenol, but no antihistamine like Benadryl. Could you tell me what is hydrocortisone used for? I also think Tylenol reduces platelet count though that may happen with prolonged use.

I have one more questions for you - has your transfusion requirement increased over the years or have you been on a similar frequency for last 10 years? I am always worried for my mother that her disease will progress and she will need even higher frequency of transfusions. No treatment has worked so far.
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Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
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  #6  
Old Thu Jul 17, 2014, 09:40 PM
usaf1125 usaf1125 is offline
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Iron overload

I have no idea what the Hydrocortisone is for, I don't dwell on anything, I do what my Doctors tell me to do and what to take. In the last year and a half my infusions have gone from every 2 or 3 weeks, to 6,7,8,9 weeks. Crt goes up and down, 29.5, next time 30.8. I have had 348 units of PRC. It is strange
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82 yr. old male. Diagnosed in 2003. Started Blood infusion 1/5/2004, average of 2 units every 2 weeks. Inject Procrit weekly 40,000 ML. I have had 344 units of PRC. E Mail leojean@comcast.net
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  #7  
Old Sat Jul 19, 2014, 02:43 PM
Mseth Mseth is offline
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Hi usaf1125,

Thanks for your reply. It's great that you are requiring less transfusions, are you on some active treatment regime that is helping? What is CRT? I tried to google CRT but could not find anything relevant.

Thanks.
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Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
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