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Transfusions and Iron Overload Blood and platelet transfusions, iron testing and treatments

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  #51  
Old Thu Apr 3, 2014, 05:38 AM
Birgitta-A Birgitta-A is offline
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IP6 Inositol

Hi Caregiver,
IP6 is Inositol. The drug is supposed to be an iron chelater but can also chelate magnesium, cupper, zinc and other metals. As Marlene writes the balance between these metals is very important.
kind regards
Birgitta-A
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  #52  
Old Thu Apr 3, 2014, 11:12 AM
Marlene Marlene is offline
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From everything I've read on IP6, it's not going to be very effective when iron is very high. You would need to take very large doses and I'm just not a fan of that. All antioxidants have some level of chelation properties but they are not very efficient in extreme cases that occur with transfusions. I don't think you would see any movement in iron levels.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of January 2017, FE is 233, HGB 11.7, WBC 5.1/ANC 4.0, Plts 146K.
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  #53  
Old Thu Apr 3, 2014, 12:28 PM
Mseth Mseth is offline
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Hi Birgitta-A,

Yes maybe some hidden infection leading to high ferritin. She also had unexpected lower than usual counts during this blood test, could this also be due to an infection?
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Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
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  #54  
Old Thu Apr 3, 2014, 02:16 PM
Birgitta-A Birgitta-A is offline
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Infections and low counts

Hi Mseth,
Yes, infections can decrease all counts - that is why I always live like I have low WBC even when they really are OK. Three times the neutrophils have been so low that I got fever (38.5) and had to go to the hospital for antibiotic intravenously.
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Birgitta-A
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